ArticleJournal of cardiothoracic and vascular anesthesia2019
Noninvasive Administration of Inhaled Nitric Oxide and its Hemodynamic Effects in Patients With Acute Right Ventricular Dysfunction.
Article in Journal of cardiothoracic and vascular anesthesia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 21 citations in OpenAlex.
- Gas mixture in noninvasive ventilation.Medical gas research · 2026Review
- Inhaled nitric oxide therapy is effective in improving right ventricular function in patients receiving ECPELLA support.General thoracic and cardiovascular surgery · 2026Article
- Phase 2 Study to Evaluate the Efficacy and Safety of Inhaled Nitric Oxide Therapy in Patients With Severe Right Heart Failure Associated With Pulmonary Hypertension - Protocol for the PHiNO Study.Circulation reports · 2025Article
- Current status of inhaled nitric oxide therapy for lung transplantation in Japan: a nationwide survey.General thoracic and cardiovascular surgery · 2021Article
- Impact of Helium-Oxygen Administered via High Velocity Nasal Insufflation on Delivery of Inhaled Nitric Oxide.Journal of pediatric intensive care · 2020Article
- Nasally Inhaled Nitric Oxide for Sudden Right-Sided Heart Failure in the Intensive Care Unit: NO Time Like the Present.Journal of cardiothoracic and vascular anesthesia · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe authors aimed to assess the hemodynamic effects and demonstrate the feasibility of inhaled nitric oxide (iNO) in hemodynamically unstable patients with acute right ventricular (RV) dysfunction and to explore the safety profile of this approach.
designRetrospective cohort study.
settingIntensive care unit (ICU) of 2 tertiary care centers between January 2013 and 2017.
participantsAll patients with RV dysfunction in whom iNO was initiated without invasive mechanical ventilation.
interventionNoninvasive administration of iNO. MEASUREMENTS AND MAIN
resultsEighteen patients received the intervention during the study period; 8 of these patients had a pulmonary artery catheter and 2 had a pulse contour analysis device. Median (interquartile range) iNO concentration was 20 (20-20) ppm, and therapy duration was 24 (12-46) hours. Most patients received iNO through nasal prongs (66.7%) or a high-flow nasal cannula (27.8%). Within 1 hour, iNO reduced pulmonary vascular resistance from 219.1 to 165.4 dyn•s/cm
conclusionNoninvasively administered iNO was associated with favorable hemodynamic effects in ICU patients with acute RV dysfunction. These results suggest the safety and feasibility of this therapy for which further prospective study is warranted.
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Registered trials
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