Evidence map›Paper›PMID 30205856›Full record

SynthesisThe British journal of nutrition2018

Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function.

Jiayi Xu, Traci M Bartz, Geetha Chittoor, Gudny Eiriksdottir, Ani W Manichaikul, Fangui Sun, Natalie Terzikhan, Xia Zhou, Sarah L Booth, Guy G Brusselle and 36 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The British journal of nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Genetic Ancestry-dependent Differences in Breast Cancer-induced Field Defects in the Tumor-adjacent Normal Breast.Clinical cancer research : an official journal of the American Association for Cancer Research · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors at 20 institutions in 4 countries.

Jiayi Xu1Division of Nutritional Sciences,Cornell University,Ithaca,NY 14853,USA.
Traci M Bartz2Department of Biostatistics,University of Washington,Seattle,WA 98195,USA.
Geetha Chittoor4Department of Biomedical and Translational Informatics,Geisinger,Danville,PA 17822,USA.
Gudny Eiriksdottir6Icelandic Heart Association,Holtasmari 1, 201 Kópavogur,Iceland.
Ani W Manichaikul7Center for Public Health Genomics,University of Virginia School of Medicine,Charlottesville,VA 22903,USA.
Fangui Sun8Department of Biostatistics,Boston University School of Public Health,Boston,MA 02118,USA.
Natalie Terzikhan9Department of Respiratory Medicine,Ghent University Hospital,9000 Ghent,Belgium.
Xia Zhou11Division of Epidemiology and Community Health,University of Minnesota,Minneapolis,MN 55454,USA.
Sarah L Booth12Jean Mayer-US Department of Agriculture Human Nutrition Research Center on Aging,Tufts University,Boston,MA 02111,USA.
Guy G Brusselle9Department of Respiratory Medicine,Ghent University Hospital,9000 Ghent,Belgium.
Ian H de Boer14Department of Medicine,University of Washington,Seattle,WA 98195,USA.
Myriam Fornage15Institute of Molecular Medicine,University of Texas Health Science Center at Houston,Houston,TX 77030,USA.
Alexis C Frazier-Wood17Children's Nutrition Research Center,Baylor College of Medicine,Houston,TX 77030,USA.
Mariaelisa Graff5Department of Epidemiology,Gillings School of Global Public Health,University of North Carolina at Chapel Hill,Chapel Hill,NC 27599,USA.
Vilmundur Gudnason6Icelandic Heart Association,Holtasmari 1, 201 Kópavogur,Iceland.
Tamara B Harris19Laboratory of Epidemiology, Demography, and Biometry,National Institute on Aging,National Institutes of Health,Department of Health and Human Services, Bethesda,MD 20892,USA.
Albert Hofman10Department of Epidemiology,Erasmus Medical Center,3000 CA Rotterdam,the Netherlands.
Ruixue Hou22Department of Nutrition and Nutrition Research Institute,University of North Carolina at Chapel Hill,Kannapolis,NC 28081,USA.
Denise K Houston23Sticht Center on Aging,Wake Forest School of Medicine,Winston-Salem,NC 27157,USA.
David R Jacobs11Division of Epidemiology and Community Health,University of Minnesota,Minneapolis,MN 55454,USA.ORCID 0000-0002-7232-0543
Stephen B Kritchevsky23Sticht Center on Aging,Wake Forest School of Medicine,Winston-Salem,NC 27157,USA.
Jeanne Latourelle26The Pulmonary Center,Department of Medicine,Boston University,Boston,MA 02118,USA.
Rozenn N Lemaitre3Cardiovascular Health Research Unit,University of Washington,Seattle,WA 98101,USA.
Pamela L Lutsey11Division of Epidemiology and Community Health,University of Minnesota,Minneapolis,MN 55454,USA.
George O'Connor26The Pulmonary Center,Department of Medicine,Boston University,Boston,MA 02118,USA.
Elizabeth C Oelsner28Department of Medicine,Columbia University,New York,NY 10032,USA.
James S Pankow11Division of Epidemiology and Community Health,University of Minnesota,Minneapolis,MN 55454,USA.
Bruce M Psaty3Cardiovascular Health Research Unit,University of Washington,Seattle,WA 98101,USA.
Rebecca R Rohde5Department of Epidemiology,Gillings School of Global Public Health,University of North Carolina at Chapel Hill,Chapel Hill,NC 27599,USA.
Stephen S Rich7Center for Public Health Genomics,University of Virginia School of Medicine,Charlottesville,VA 22903,USA.
Jerome I Rotter32Institute for Translational Genomics and Population Sciences,Los Angeles Biomedical Research Institute and Department of Pediatrics at Harbor-UCLA Medical Center,Torrance,CA 90502,USA.
Lewis J Smith33Division of Pulmonary and Critical Care,Feinberg School of Medicine,Northwestern University,Chicago,IL 60611,USA.
Bruno H Stricker10Department of Epidemiology,Erasmus Medical Center,3000 CA Rotterdam,the Netherlands.
V Saroja Voruganti22Department of Nutrition and Nutrition Research Institute,University of North Carolina at Chapel Hill,Kannapolis,NC 28081,USA.
Thomas J Wang34Division of Cardiovascular Medicine,Department of Medicine,Vanderbilt University,Nashville,TN 37232,USA.
M Carola Zillikens20Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging,2333 ZC Leiden,The Netherlands.
R Graham Barr28Department of Medicine,Columbia University,New York,NY 10032,USA.
Josée Dupuis8Department of Biostatistics,Boston University School of Public Health,Boston,MA 02118,USA.
Sina A Gharib14Department of Medicine,University of Washington,Seattle,WA 98195,USA.
Lies Lahousse9Department of Respiratory Medicine,Ghent University Hospital,9000 Ghent,Belgium.
Stephanie J London38Division of Intramural Research,National Institute of Environmental Health Sciences,National Institutes of Health, Department of Health and Human Services,Research Triangle Park,NC 27709,USA.
Kari E North5Department of Epidemiology,Gillings School of Global Public Health,University of North Carolina at Chapel Hill,Chapel Hill,NC 27599,USA.
Albert V Smith6Icelandic Heart Association,Holtasmari 1, 201 Kópavogur,Iceland.
Lyn M Steffen11Division of Epidemiology and Community Health,University of Minnesota,Minneapolis,MN 55454,USA.
Dana B Hancock39Center for Omics Discovery and Epidemiology, Behavioral Health Research Division,RTI International,Research Triangle Park,NC 27709,USA.
Patricia A Cassano1Division of Nutritional Sciences,Cornell University,Ithaca,NY 14853,USA.
University of North Carolina at Chapel Hill · USUniversity of Minnesota · USBoston University · USUniversity of Washington · USGhent University Hospital · BEColumbia University · USCornell University · USErasmus MC · NLNational Institutes of Health · USUniversity of Iceland · ISUniversity of Virginia · USWake Forest University · USBaylor College of Medicine · USHarvard University · USIcelandic Heart Association · ISKaiser Permanente Washington Health Research Institute · USNorthwestern University · USRTI International · USThe Lundquist Institute · USThe University of Texas Health Science Center at Houston · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2M
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Genome-wide case-only study of antihypertensive drug-gene interactionsR01HL085251 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2007 to 2010
$7.2M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
Prospective meta-analyses of drug-gene interactions: CHARGE GWAS consortiumR01HL103612 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2011 to 2014
$5.4M
Intramural NIH HHS Z01 ES043012NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001881NHLBI NIH HHS K23 HL130627NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL084443NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL096875NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL103706NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R21 HL125574NHLBI NIH HHS RC1 HL100543NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062106NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG028050NIA NIH HHS R01 AG029364NIA NIH HHS RC1 AG035835NIDDK NIH HHS P30 DK063491NINR NIH HHS R01 NR012459
6 · The paper itself

Abstract

The role that vitamin D plays in pulmonary function remains uncertain. Epidemiological studies reported mixed findings for serum 25-hydroxyvitamin D (25(OH)D)-pulmonary function association. We conducted the largest cross-sectional meta-analysis of the 25(OH)D-pulmonary function association to date, based on nine European ancestry (EA) cohorts (n 22 838) and five African ancestry (AA) cohorts (n 4290) in the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Data were analysed using linear models by cohort and ancestry. Effect modification by smoking status (current/former/never) was tested. Results were combined using fixed-effects meta-analysis. Mean serum 25(OH)D was 68 (sd 29) nmol/l for EA and 49 (sd 21) nmol/l for AA. For each 1 nmol/l higher 25(OH)D, forced expiratory volume in the 1st second (FEV1) was higher by 1·1 ml in EA (95 % CI 0·9, 1·3; P<0·0001) and 1·8 ml (95 % CI 1·1, 2·5; P<0·0001) in AA (P race difference=0·06), and forced vital capacity (FVC) was higher by 1·3 ml in EA (95 % CI 1·0, 1·6; P<0·0001) and 1·5 ml (95 % CI 0·8, 2·3; P=0·0001) in AA (P race difference=0·56). Among EA, the 25(OH)D-FVC association was stronger in smokers: per 1 nmol/l higher 25(OH)D, FVC was higher by 1·7 ml (95 % CI 1·1, 2·3) for current smokers and 1·7 ml (95 % CI 1·2, 2·1) for former smokers, compared with 0·8 ml (95 % CI 0·4, 1·2) for never smokers. In summary, the 25(OH)D associations with FEV1 and FVC were positive in both ancestries. In EA, a stronger association was observed for smokers compared with never smokers, which supports the importance of vitamin D in vulnerable populations.

Indexed as

AgingRespiratory Function TestsAdultAgedBlack or African AmericanBlack PeopleCross-Sectional StudiesFemaleForced Expiratory VolumeGenome, HumanHeartHeart DiseasesHumansLungLung DiseasesMale25-hydroxyvitamin DVitamin D125-dihydroxyvitamin D25-(OH)2D 125(OH)D 25-hydroxyvitamin DAA African ancestryAfrican AmericansAGES AgeAgingand Body Composition StudyARIC Atherosclerosis Risk in Communities StudyCARDIA Coronary Artery Risk Development in Young Adults StudyCHARGE Cohorts for Heart and Aging Research in Genomic EpidemiologyCHS Cardiovascular Health StudyCOPD chronic obstructive pulmonary diseaseEA European ancestryEnvironmentFEV1 forced expiratory volume in the 1st secondFHS (Gen3) Framingham Heart Study – Generation 3 CohortFHS (Offspring) Framingham Heart Study –Offspring CohortForced expiratory volumeFVC forced vital capacityGeneHABC HealthIcelandMESA Multi-Ethnic Study of AtherosclerosisPFT pulmonary function testRespiratory function testsRIA radioimmunoassaySmokingSusceptibility Study − ReykjavikVital capacityVitamin DWhites

Identifiers

PMID30205856
PMCPMC6263170
OpenAlexW2889916565

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.