Evidence map›Paper›PMID 30205592›Full record

ReviewMolecules (Basel, Switzerland)2018

Antiviral Activities of Oleanolic Acid and Its Analogues.

Vuyolwethu Khwaza, Opeoluwa O Oyedeji, Blessing A Aderibigbe

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.

  1. The Antiviral Potential ofMolecules (Basel, Switzerland) · 2024
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  11. Emerging Nanotechnology for the Treatment of Alzheimer's Disease.CNS & neurological disorders drug targets · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Vuyolwethu KhwazaDepartment of Chemistry, University of Fort Hare, Alice Campus, Alice 5700, Eastern Cape, South Africa. vuyolwethukhwaza@gmail.com.
Opeoluwa O OyedejiDepartment of Chemistry, University of Fort Hare, Alice Campus, Alice 5700, Eastern Cape, South Africa. ooyedeji@ufh.ac.za.
Blessing A AderibigbeDepartment of Chemistry, University of Fort Hare, Alice Campus, Alice 5700, Eastern Cape, South Africa. blessingaderibigbe@gmail.com.
University of Fort Hare · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Viral diseases, such as human immune deficiency virus (HIV), influenza, hepatitis, and herpes, are the leading causes of human death in the world. The shortage of effective vaccines or therapeutics for the prevention and treatment of the numerous viral infections, and the great increase in the number of new drug-resistant viruses, indicate that there is a great need for the development of novel and potent antiviral drugs. Natural products are one of the most valuable sources for drug discovery. Most natural triterpenoids, such as oleanolic acid (OA), possess notable antiviral activity. Therefore, it is important to validate how plant isolates, such as OA and its analogues, can improve and produce potent drugs for the treatment of viral disease. This article reports a review of the analogues of oleanolic acid and their selected pathogenic antiviral activities, which include HIV, the influenza virus, hepatitis B and C viruses, and herpes viruses.

Indexed as

Antiviral AgentsDrug Resistance, Multiple, ViralDrug SynergismHumansOleanolic AcidPentacyclic TriterpenesPlant ExtractsPlants, MedicinalAntiviral AgentsOleanolic AcidPentacyclic TriterpenesPlant ExtractsHBV/HCVHIVinfluenza virusmedicinal plantnatural producttriterpenoids

Identifiers

PMID30205592
PMCPMC6225463
OpenAlexW2890948560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.