Evidence map›Paper›PMID 30205577›Full record

ArticleInternational journal of molecular sciences2018

lncRNAs in Non-Malignant Tissue Have Prognostic Value in Colorectal Cancer.

Jana-Aletta Thiele, Petr Hosek, Eva Kralovcova, Pavel Ostasov, Vaclav Liska, Jan Bruha, Ondrej Vycital, Jachym Rosendorf, Alena Opattova, Josef Horak and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Prognostic Value ofBiomolecules · 2022
    Article
  8. Article
  9. Article
  10. Identification of NNeurosurgical review · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Special Issue on Basic and Translational Research in Colorectal Cancer.International journal of molecular sciences · 2019
    Article
  16. SalivaryPeerJ · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Jana-Aletta ThieleBiomedical Centre, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 32300 Pilsen, Czech Republic. Jana.A.Thiele@lfp.cuni.cz.
Petr HosekBiomedical Centre, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 32300 Pilsen, Czech Republic. petr.hosek@lfp.cuni.cz.ORCID 0000-0002-9359-4770
Eva KralovcovaBiomedical Centre, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 32300 Pilsen, Czech Republic. Eva.Kralovcova@lfp.cuni.cz.
Pavel OstasovBiomedical Centre, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 32300 Pilsen, Czech Republic. Pavel.Ostasov@lfp.cuni.cz.ORCID 0000-0001-7168-6431
Vaclav LiskaBiomedical Centre, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 32300 Pilsen, Czech Republic. liskav@fnplzen.cz.
Jan BruhaBiomedical Centre, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 32300 Pilsen, Czech Republic. bruhaj@fnplzen.cz.
Ondrej VycitalBiomedical Centre, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 32300 Pilsen, Czech Republic. vycitalo@fnplzen.cz.
Jachym RosendorfBiomedical Centre, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 32300 Pilsen, Czech Republic. rosendorfj@fnplzen.cz.
Alena OpattovaBiomedical Centre, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 32300 Pilsen, Czech Republic. alenaopattova@gmail.com.ORCID 0000-0002-4508-6560
Josef HorakBiomedical Centre, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 32300 Pilsen, Czech Republic. horajozka@seznam.cz.
Milena KralickovaBiomedical Centre, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 32300 Pilsen, Czech Republic. Milena.Kralickova@lfp.cuni.cz.
Pavel VodickaBiomedical Centre, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 32300 Pilsen, Czech Republic. pvodicka@biomed.cas.cz.
Pavel PituleBiomedical Centre, Faculty of Medicine in Pilsen, Charles University, Alej Svobody 76, 32300 Pilsen, Czech Republic. pavel.pitule@lfp.cuni.cz.ORCID 0000-0002-3150-2914
Charles University · CZ

Funding

Ministerstvo Školství, Mládeže a Tělovýchovy National Sustainability Program I (NPU I) Nr. LO1503Univerzita Karlova v Praze Progres Q39Univerzita Karlova v Praze UNCE/MED/006 "University Center of Clinical and Experimental Liver Surgery"
6 · The paper itself

Abstract

Although colorectal cancer (CRC) is the third most frequent cause of cancer related death in Europe, clinically relevant biomarkers for therapy guidance and prognosis are insufficiently reliable. Long non-coding RNAs (lncRNAs) are RNAs over 200 nucleotides long that are not translated into proteins but can influence biological processes. There is emerging evidence for their involvement in solid cancer as oncogenes, tumour suppressors or regulators of cell proliferation and metastasis development. The goal of this study was to evaluate the prognostic effect of selected lncRNAs in a retrospective study on CRC patients from the Czech Republic. We used a quantitative PCR approach to measure the expression in paired non-malignant and tumour tissue samples of CRC patients of nine lncRNAs previously shown to be involved in cancer progression-

Indexed as

Gene Expression Regulation, NeoplasticAdultAgedBiomarkers, TumorColorectal NeoplasmsCzech RepublicFemaleHumansKaplan-Meier EstimateMaleMiddle AgedPrognosisProportional Hazards ModelsRetrospective StudiesRNA, Long NoncodingUp-RegulationBiomarkers, TumorRNA, Long NoncodingCCAT1colorectal carcinomalncRNAlncRNA ratioMIR155HGPCAT1

Identifiers

PMID30205577
PMCPMC6163783
OpenAlexW2890444526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.