Evidence map›Paper›PMID 30205124›Full record

ArticleInternational journal of radiation oncology, biology, physics2019

Prospective Immunophenotyping of CD8

Jaden D Evans, Lindsay K Morris, Henan Zhang, Siyu Cao, Xin Liu, Kristin C Mara, Bradley J Stish, Brian J Davis, Aaron S Mansfield, Roxana S Dronca and 6 more

Abstract read
In one paragraph

Article in International journal of radiation oncology, biology, physics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Phase II Evaluation of Stereotactic Ablative Radiotherapy (SABR) and Immunity inClinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Trial
  4. Article
  5. Review
  6. Article
  7. Modulation of CD8International journal of molecular sciences · 2023
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jaden D EvansDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Lindsay K MorrisDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Henan ZhangDepartment of Immunology, Mayo Clinic, Rochester, Minnesota.
Siyu CaoDepartment of Immunology, Mayo Clinic, Rochester, Minnesota.
Xin LiuDepartment of Immunology, Mayo Clinic, Rochester, Minnesota.
Kristin C MaraDivision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.
Bradley J StishDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Brian J DavisDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Aaron S MansfieldDivision of Medical Oncology, Mayo Clinic, Rochester, Minnesota.
Roxana S DroncaDivision of Medical Oncology, Mayo Clinic, Rochester, Minnesota; Division of Medical Oncology, Mayo Clinic, Jacksonville, Florida.
Matthew J IottDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Eugene D KwonDepartment of Urology, Mayo Clinic, Rochester, Minnesota.
Robert L FooteDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Kenneth R OlivierDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Haidong DongDepartment of Immunology, Mayo Clinic, Rochester, Minnesota; Department of Urology, Mayo Clinic, Rochester, Minnesota.
Sean S ParkDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota. Electronic address: park.sean@mayo.edu.

Funding

Paul Calabresi Program in Clinical/Translational Research at Mayo ClinicK12CA090628 · NCI · MAYO CLINIC ROCHESTER · PI WEROHA, SARAVUT · 2001 to 2025
$19.7M
A Phase II Evaluation of SABR in Oligometastatic Castration-Refractory Prostate Cancer and Immunogenicity of SABRR01CA200551 · NCI · MAYO CLINIC ROCHESTER · PI DONG, HAIDONG, PARK, SEAN S · 2016 to 2018
$739k
NCI NIH HHS K12 CA090628NCI NIH HHS R01 CA200551
6 · The paper itself

Abstract

purposeThis study examined the effects of metastasis-directed stereotactic body radiation therapy (mdSBRT) on CD8 METHODS AND MATERIALS: Peripheral blood mononuclear cells were prospectively isolated from 37 patients with OPCa (≤3 metastases) who were treated with mdSBRT. Immunophenotyping identified circulating CD8

resultsMedian follow-up was 39 months (interquartile range, 34-43). Overall survival at 3 years was 78.2%. Cumulative incidence for local progression and new distant metastasis at 3 years was 16.5% and 67.6%, respectively. Between baseline and day 14 after mdSBRT, an increase in the T

conclusionsAn increase in the T

Indexed as

AgedAndrogen AntagonistsCD8-Positive T-LymphocytesHumansImmunophenotypingMaleMiddle AgedNeoplasm MetastasisProportional Hazards ModelsProspective StudiesProstatic NeoplasmsRadiosurgeryAndrogen Antagonists

Identifiers

PMID30205124
PMCPMC6301146

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.