ArticleSocial cognitive and affective neuroscience2018
Physical pain recruits the nucleus accumbens during social distress in borderline personality disorder.
Article in Social cognitive and affective neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Biological research on mental pain, social pain and other pains not primarily felt in the body: methodological systematic review.The British journal of psychiatry : the journal of mental science · 2025Pooled it
- The vicious circle of social exclusion and psychopathology: a systematic review of experimental ostracism research in psychiatric disorders.European archives of psychiatry and clinical neuroscience · 2020Pooled it
- Multi-voxel MR-spectroscopy signatures and associations with EEG network hyperexcitability and clinical symptomatology in borderline personality disorder.Frontiers in psychiatry · 2026Article
- Neuroanatomical and functional correlates in borderline personality disorder: A narrative review.Ibrain · 2025Review
- Aberrant glutamatergic systems underlying impulsive behaviors: Insights from clinical and preclinical research.Progress in neuro-psychopharmacology & biological psychiatry · 2024Review
- Acute, Chronic, and Everyday Physical Pain in Borderline Personality Disorder.Current psychiatry reports · 2024Review
- Brain Activation for Social Cognition and Emotion Processing Tasks in Borderline Personality Disorder: A Meta-Analysis of Neuroimaging Studies.Brain sciences · 2024Review
- Article
- Far from the eyes, far from the heart: COVID-19 confinement dampened sensitivity to painful facial features.Quarterly journal of experimental psychology (2006) · 2023Article
- Borderline Personality Disorder: Updates in a Postpandemic World.Focus (American Psychiatric Publishing) · 2022Review
- Abnormal brain activity in nonsuicidal self-injury: a coordinate-based activation likelihood meta-analysis of functional neuroimaging studies.Psychoradiology · 2021Article
- [Addictive behaviors: Clinical facts].Bulletin de l'Academie nationale de medecine · 2020Review
- Co-Occurring Autism Spectrum and Borderline Personality Disorder: An Emerging Clinical Challenge Seeking Informed Interventions.Harvard review of psychiatryArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
Patients with borderline personality disorder (BPD) often engage in dangerous self-injurious behaviors (SIBs) as a maladaptive technique to decrease heightened feelings of distress (e.g. negative feelings caused by social exclusion). The reward system has recently been proposed as a plausible neural substrate, which may influence the interaction between social distress and physical pain processing in patients that engage in SIBs. Using functional magnetic resonance imaging (fMRI) in 20 adult BPD patients with a history of SIBs and 23 healthy controls (HCs), we found a hyper-activation of the nucleus accumbens (NAcc) and amygdala when painful stimuli were presented to BPD patients (but not HCs) in a state of heightened distress, induced via social exclusion. This differential NAcc activity was mediated by anxious attachment style, which is a key developmental feature of the disorder. Altogether, these results suggest a neural mechanism underlying the pathophysiology of SIBs in these patients, which is likely reinforced via the reward system.
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