ArticlePloS one2018
Association between adaptive immunity and neutrophil dynamics in zebrafish (Danio rerio) infected by a parasitic ciliate.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- A portrait of 2 nematodes in liver of their paratenic fish hosts, illustrating different immunological approaches.Parasitology · 2025Article
- Infection of endemic chubParasitology · 2024Article
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- The immune responses of Oreochromis niloticus against Prohemistomum vivax encysted metacercariae infection with the evaluation of different biomarkers stressors.Scientific reports · 2023Article
- Acute immune responses in zebrafish and evasive behavior of a parasite - who is winning?Frontiers in cellular and infection microbiology · 2023Article
- Teleost innate immunity, an intricate game between immune cells and parasites of fish organs: who wins, who loses.Frontiers in immunology · 2023Review
- Effects of vasicine in neuroinflammatory zebrafish model.Bioinformation · 2023Article
- Neutrophils and aquatic pathogens.Parasite immunology · 2022Review
- Don't Let It Get Under Your Skin! - Vaccination Protects the Skin Barrier of Common Carp From Disruption Caused by Cyprinid Herpesvirus 3.Frontiers in immunology · 2022Article
- Responses towards eyefluke (Diplostomum pseudospathaceum) in different genetic lineages of rainbow trout.PloS one · 2022Article
- Mucosal immunoglobulins of teleost fish: A decade of advances.Developmental and comparative immunology · 2021Review
- Polydatin Beneficial Effects in Zebrafish Larvae Undergoing Multiple Stress Types.International journal of environmental research and public health · 2021Article
- Dual-Organ Transcriptomic Analysis of Rainbow Trout Infected WithFrontiers in immunology · 2021Article
- Quantitative trait loci (QTL) associated with resistance of rainbow trout Oncorhynchus mykiss against the parasitic ciliate Ichthyophthirius multifiliis.Journal of fish diseases · 2020Article
- Immune response to Ichthyophthirius multifiliis and role of IgT.Parasite immunology · 2020Review
- Zebrafish as a Model for Fish Diseases in Aquaculture.Pathogens (Basel, Switzerland) · 2020Review
- Leveraging the zebrafish to model organ transplantation.Current opinion in organ transplantation · 2019Review
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The protective immune response in zebrafish (Danio rerio) against the parasitic ciliate Ichthyophthirius multifiliis, targeting host skin, fins and gills, comprises an accelerated and manifold elevated immunoglobulin gene expression as well as a significantly elevated number of neutrophils at infected sites. Experimental fish were subjected to a primary I. multifiliis infection followed by a series of secondary exposures before they were challenged by a high dosage of infective theronts. Immunized fish responded immediately with a protective response suggesting existence of immunological memory whereas fish exposed to the parasite for the first time obtained a marked infection. The primary response to infection was dominated by expression of genes encoding acute phase reactants and inflammatory cytokines as well as recruitment of neutrophils at infected locations. Immunized fish showed a significantly upregulated immunoglobulin gene expression following challenge, which indicates existence of a secondary response effected by antibodies. Both responses induced a significantly elevated expression of the Th2 signature cytokine Il13. The increased presence of neutrophils in immunized fish suggests that innate cell mediated immunity supplements or influence the protective response against the parasite.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.