ArticleObstetrics and gynecology2018
Choice of Prophylactic Antibiotics and Surgical Site Infections After Cesarean Delivery.
Article in Obstetrics and gynecology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Effect of prophylactic use of cefazolin in caesarean section on postoperative infection: A meta-analysis.International wound journal · 2024Pooled it
- Comparing prophylactic use of cefazolin for SSI in cesarean section: a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2021Pooled it
- Indirect comparison of efficacy between different antibiotic prophylaxis against the intracranial infection after craniotomy.Antimicrobial resistance and infection control · 2020Pooled it
- Impact of beta-lactam allergy labels on antibiotic prophylaxis and surgical site infections after cesarean section; a retrospective study.Antimicrobial resistance and infection control · 2026Article
- Reducing post-cesarean sepsis: Current best practice in prevention and treatment.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Article
- Multimodal assessment of the prevention of surgical site infections in breast surgery in a French university hospital.Antimicrobial resistance and infection control · 2025Observational
- Risk Assessment of Surgical Site Infections After Cesarean Delivery in Patients with Gestational Diabetes Cases.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Comparing Antibiotic Regimens for Preventing Infections After Planned Cesarean Delivery.O&G open · 2025Article
- A comprehensive study on the risk factors and pathogen analysis of postoperative wound infections following caesarean section procedures.International wound journal · 2024Article
- [Antibiotic allergies: targeted approach in suspected β‑lactam allergy].Urologie (Heidelberg, Germany) · 2023Article
- [Antibiotic allergies: targeted approach in suspected β‑lactam allergy].Innere Medizin (Heidelberg, Germany) · 2023Article
- DocumentedInfectious diseases in obstetrics and gynecology · 2022Article
- Penicillin Allergy Delabeling: A Multidisciplinary Opportunity.The journal of allergy and clinical immunology. In practice · 2020Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo examine the rate of surgical site infection according to the choice of antibiotics in women undergoing cesarean delivery.
methodsWe conducted a retrospective cohort study of women undergoing cesarean delivery (labored, unlabored, and scheduled) from 2012 to 2017. Women with chorioamnionitis and those who did not receive any antibiotics were excluded. Our primary outcome was defined a priori as a composite of cellulitis, endometritis, deep wound infection, abdominopelvic abscess, and sepsis. Outcomes were examined according to the choice of antibiotics: cefazolin, a standard alternative (both clindamycin and gentamicin), and inappropriate alternatives (such as clindamycin only). A multivariable logistic regression model was used to calculate the propensity score for each observation, which was the probability of receiving a particular antibiotic regimen. The propensity score-adjusted logistic regression models were conducted to calculate adjusted odds ratios (ORs) and 95% CIs. Firth's penalized likelihood approach was applied to address issues of rare events.
resultsAmong 6,584 selected women, 6,163 (93.6%), 274 (4.2%), and 147 (2.2%) received cefazolin, a standard alternative, and inappropriate alternatives, respectively. Use of standard alternative antibiotics compared with cefazolin was not associated with increased odds of the primary outcome (crude OR 1.50 [0.92-2.46]; adjusted OR 1.63 [0.97-2.60]) but was associated with increased odds of cellulitis (crude OR 2.07 [1.16-3.70]; adjusted OR 1.93 [1.03-3.31]). Use of inappropriate alternative antibiotics compared with cefazolin was associated with increased odds of the primary outcome (crude OR 4.37 [2.80-6.83]; adjusted OR 4.13 [2.59-6.36]) as well as some components of the composite outcome such as endometritis before discharge (crude OR 6.85 [3.94-11.90]; adjusted OR 6.68 [3.69-11.44]) and cellulitis (crude OR 3.36 [1.78-6.34]; adjusted OR 3.23 [1.63-5.81]).
conclusionBoth standard alternative and inappropriate alternatives were associated with increased odds of surgical site infections compared with cefazolin.
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