ArticleOrganic letters2018
Benign Synthesis of Thiazolo-androstenone Derivatives as Potent Anticancer Agents.
Article in Organic letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Efficient Synthesis of Thiazole-Fused Bisnoralcohol Derivatives as Potential Therapeutic Agents.ACS omega · 2024Article
- Pyrazole: an emerging privileged scaffold in drug discovery.Future medicinal chemistry · 2023Review
- Domino/Cascade and Multicomponent Reactions for the Synthesis of Thiazole Derivatives.Current organic chemistry · 2022Article
- Synthesis of Chimeric Thiazolo-Nootkatone Derivatives as Potent Antimicrobial Agents.ChemMedChem · 2021Article
- Antimelanoma activities of chimeric thiazole-androstenone derivatives.Royal Society open science · 2021Article
- Benign Synthesis of Fused-thiazoles with Enone-based Natural Products and Drugs for Lead Discovery.New journal of chemistry = Nouveau journal de chimie · 2021Article
- Article
- Synthesis of Hydrazone Derivatives of 4-[4-Formyl-3-(2-oxochromen-3-yl)pyrazol-1-yl]benzoic acid as Potent Growth Inhibitors of Antibiotic-resistantMolecules (Basel, Switzerland) · 2019Article
- Hexafluoroisopropanol-Mediated Domino Reaction for the Synthesis of Thiazolo-androstenones: Potent Anticancer Agents.ACS omega · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
An unprecedented reaction of thiourea derivatives with 6β-bromoandrostenedione has been discovered for the formation of aminothiazolo-androstenones via a simple, safer, cascade protocol that enables the syntheses of novel molecules by using readily available reagents. The reaction mechanism of product formation has been rationalized by density functional theory calculations. This benign methodology accentuates a domino protocol deploying a renewable solvent, ethanol, while generating novel compounds that display potent growth inhibitory effects in in vitro studies for several cancer cell lines at submicromolar concentrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.