ArticleSoft matter2018
Nonequilibrium phase diagrams for actomyosin networks.
Article in Soft matter, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Rethinking contractility in active cytoskeletal matter.Biophysical journal · 2026Article
- An active matter model captures spatial dynamics of actomyosin oscillations in larval epithelial cells duringProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Polarity sorting of actin filaments by motor-driven cargo transport.Biophysical journal · 2025Article
- Morphometric analysis of actin networks.Molecular biology of the cell · 2024Article
- Motor crosslinking augments elasticity in active nematics.Soft matter · 2024Article
- A coarse-grained simulation model for colloidal self-assemblySoft matter · 2023Article
- Active layer dynamics drives a transition to biofilm fingering.NPJ biofilms and microbiomes · 2023Article
- Organization and dynamics of cross-linked actin filaments in confined environments.Biophysical journal · 2023Article
- Thermodynamic Control of Activity Patterns in Cytoskeletal Networks.Physical review letters · 2022Article
- Actin crosslinker competition and sorting drive emergent GUV size-dependent actin network architecture.Communications biology · 2021Article
- Protein friction and filament bending facilitate contraction of disordered actomyosin networks.Biophysical journal · 2021Article
- Detailed Balance Broken by Catch Bond Kinetics Enables Mechanical-Adaptation in Active Materials.Advanced functional materials · 2021Article
- The Actin Cytoskeleton as an Active Adaptive Material.Annual review of condensed matter physics · 2020Article
- Stratification relieves constraints from steric hindrance in the generation of compact actomyosin asters at the membrane cortex.Science advances · 2020Article
- Dynamic motions of molecular motors in the actin cytoskeleton.Cytoskeleton (Hoboken, N.J.) · 2019Article
- Mechanical and kinetic factors drive sorting of F-actin cross-linkers on bundles.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Remarkable structural transformations of actin bundles are driven by their initial polarity, motor activity, crosslinking, and filament treadmilling.PLoS computational biology · 2019Article
- Quantifying dissipation in actomyosin networks.Interface focus · 2019Article
- Mobility of Molecular Motors Regulates Contractile Behaviors of Actin Networks.Biophysical journal · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Living cells dynamically modulate the local morphologies of their actin networks to perform biological functions, including force transduction, intracellular transport, and cell division. A major challenge is to understand how diverse structures of the actin cytoskeleton are assembled from a limited set of molecular building blocks. Here we study the spontaneous self-assembly of a minimal model of cytoskeletal materials, consisting of semiflexible actin filaments, crosslinkers, and molecular motors. Using coarse-grained simulations, we demonstrate that by changing concentrations and kinetics of crosslinkers and motors, as well as filament lengths, we can generate three distinct structural phases of actomyosin assemblies: bundled, polarity-sorted, and contracted. We introduce new metrics to distinguish these structural phases and demonstrate their functional roles. We find that the binding kinetics of motors and crosslinkers can be tuned to optimize contractile force generation, motor transport, and mechanical response. By quantitatively characterizing the relationships between the modes of cytoskeletal self-assembly, the resulting structures, and their functional consequences, our work suggests new principles for the design of active materials.
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