Evidence map›Paper›PMID 30204085›Full record

ArticleeLife2018

Identification of cryptic subunits from an apicomplexan ATP synthase.

Diego Huet, Esther Rajendran, Giel G van Dooren, Sebastian Lourido

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
6.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 85 citations in OpenAlex.

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  12. The Effects and Mechanism of ATM Kinase Inhibitors inInternational journal of molecular sciences · 2024
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  17. SPARK regulates AGC kinases central to thebioRxiv : the preprint server for biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Diego HuetWhitehead Institute for Biomedical Research, Cambridge, United States.
Esther RajendranResearch School of Biology, Australian National University, Canberra, Australia.
Giel G van DoorenResearch School of Biology, Australian National University, Canberra, Australia.ORCID 0000-0003-2455-9821
Sebastian LouridoWhitehead Institute for Biomedical Research, Cambridge, United States.ORCID 0000-0002-5237-1095
Australian National University · AUWhitehead Institute for Biomedical Research · US

Funding

Dissecting essential signaling pathways in apicomplexan parasitesDP5OD017892 · OD · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI LOURIDO, SEBASTIAN · 2013 to 2017
$2.4M
Identification of novel Toxoplasma genes involved in host-parasite interactionsR21AI123746 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI LOURIDO, SEBASTIAN · 2016 to 2017
$536k
Understanding the highly divergent mitochondrial ATP synthase in T. gondiiK99AI137218 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI HUET, DIEGO · 2018 to 2019
$274k
NIAID NIH HHS K99 AI137218NIAID NIH HHS R21 AI123746NIH HHS 1DP5OD017892NIH HHS 1R21AI123746NIH HHS DP5 OD017892NIH HHS K99AI137218
6 · The paper itself

Abstract

The mitochondrial ATP synthase is a macromolecular motor that uses the proton gradient to generate ATP. Proper ATP synthase function requires a stator linking the catalytic and rotary portions of the complex. However, sequence-based searches fail to identify genes encoding stator subunits in apicomplexan parasites like

Indexed as

Amino Acid SequenceAnimalsCattleConserved SequenceMitochondriaMitochondrial Proton-Translocating ATPasesProtein ConformationProtein SubunitsProtozoan ProteinsStructural Homology, ProteinToxoplasmaMitochondrial Proton-Translocating ATPasesProtein SubunitsProtozoan ProteinsApicomplexaATP synthasecell biologyinfectious diseasemicrobiologymitochondriaToxoplasma gondii

Identifiers

PMID30204085
PMCPMC6133553
OpenAlexW2952197919

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.