ArticleeLife2018
Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Intellectual Disability and Potassium Channelopathies: A Systematic Review.Frontiers in genetics · 2020Pooled it
- BRAINCELL modelling platform for stochastic nanoscale organisation and dynamic extracellular signalling among neurons and glia.Nature communications · 2026Article
- Beyond Neurodegeneration: White Matter Vacuolation as a Primary Myelin Defect.International journal of molecular sciences · 2026Review
- Myelin Repair as a Neuroprotective Strategy for Multiple Sclerosis: From Bench to Bedside.Medicina (Kaunas, Lithuania) · 2026Review
- Myelin sheaths in the central nervous system can withstand damage and dynamically remodel.Science (New York, N.Y.) · 2026Article
- COUNTERING AGE-ASSOCIATED ALTERATIONS IN OLIGODENDROCYTE-DERIVED EXTRACELLULAR MATRIX REJUVENATES COGNITION.bioRxiv : the preprint server for biology · 2026Article
- Unraveling the Role of Ensheathing Cells and Perineural Fibroblasts in Olfactory Neurogenesis.Glia · 2025Article
- Activation of Kir4.1 Channels by 2-D08 Promotes Myelin Repair in Multiple Sclerosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Roles of Ion Channels in Oligodendrocyte Precursor Cells: From Physiology to Pathology.International journal of molecular sciences · 2025Review
- Neuroprotective strategies in multiple sclerosis: a status update and emerging paradigms.Expert review of neurotherapeutics · 2025Review
- Activity-driven myelin sheath growth is mediated by mGluR5.Nature neuroscience · 2025Article
- Review
- Preclinical Insights into the Role of Kir4.1 in Chronic Pain and Depression: Mechanisms and Therapeutic Potential.Biomolecules · 2025Review
- Inflammation's impact on the interaction between oligodendrocytes and axons.Discovery immunology · 2025Review
- Heterogeneity in oligodendrocyte precursor cell proliferation is dynamic and driven by passive bioelectrical properties.Cell reports · 2024Article
- Anesthetic effects on electrophysiological responses across the visual pathway.Scientific reports · 2024Article
- Axonal neurotransmitter release in the regulation of myelination.Bioscience reports · 2024Review
- Dynamics of mature myelin.Nature neuroscience · 2024Review
- Voltage-Gated Ion Channels Are Transcriptional Targets of Sox10 during Oligodendrocyte Development.Cells · 2024Article
- Oligodendrocyte-axon metabolic coupling is mediated by extracellular KNature neuroscience · 2024Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 3 institutions in 3 countries.
Lucas SchirmerEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California, United States.ORCID http://orcid.org/0000-0001-7142-4116
Wiebke MöbiusDepartment of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.ORCID http://orcid.org/0000-0002-2902-7165
Chao ZhaoWellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.ORCID http://orcid.org/0000-0003-1144-1621
Andrés Cruz-HerranzDepartment of Neurology, University of California, San Francisco, San Francisco, United States.
Lucile Ben HaimEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California, United States.
Christian CordanoDepartment of Neurology, University of California, San Francisco, San Francisco, United States.
Lawrence R ShiowEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California, United States.
Kevin W KelleyEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California, United States.
Boguslawa SadowskiDepartment of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
Garrett TimmonsDepartment of Neurology, University of California, San Francisco, San Francisco, United States.
Anne-Katrin PröbstelDepartment of Neurology, University of California, San Francisco, San Francisco, United States.
Jackie N WrightEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California, United States.
Jung Hyung SinDepartment of Neurology, University of California, San Francisco, San Francisco, United States.
Michael DevereuxDepartment of Neurology, University of California, San Francisco, San Francisco, United States.
Daniel E MorrisonWellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
Sandra M ChangEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California, United States.
Khalida SabeurEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California, United States.
Ari J GreenDepartment of Neurology, University of California, San Francisco, San Francisco, United States.
Klaus-Armin NaveDepartment of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.ORCID http://orcid.org/0000-0001-8724-9666
Robin Jm FranklinWellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.
David H RowitchEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California, United States.ORCID http://orcid.org/0000-0002-0079-0060
University of California, San Francisco · USNanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103 · DEWellcome/MRC Cambridge Stem Cell Institute · GB
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6MOLIGODENDROCYTE LINEAGE GENE FUNCTION IN THE CNSR01NS040511 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROWITCH, DAVID H · 2000 to 2014
$6.4MAssociazione Italiana Sclerosi Multipla 2013/B/4California Institute of Regenerative Medicine Medical Scientist Training ProgramDeutsche Forschungsgemeinschaft EXC171Deutsche Forschungsgemeinschaft SCHI 1330/1-1Deutsche Forschungsgemeinschaft TR43Dr. Miriam and Sheldon G. Adelson Medical Research Foundation Collaborative research grantEuropean Commission ERC advanced grant - AxoGLIAEuropean Commission ERC advanced grant - MyeliNANOMedical Research Council MC_PC_12009Multiple Sclerosis Society Project grantNational Multiple Sclerosis Society FG-1607-25111National Multiple Sclerosis Society FG-20102-A-1NIGMS NIH HHS T32 GM007618NIH HHS NS040511NINDS NIH HHS R01 NS040511Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung P2SKP3_164938/1Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung P300PB_177927Wellcome Senior investigator grantWellcome TrustWellcome Trust Senior investigator award
Abstract
Glial support is critical for normal axon function and can become dysregulated in white matter (WM) disease. In humans, loss-of-function mutations of
Indexed as
AnimalsAxonsHumansKcnj10 ChannelLeukoencephalopathiesMiceMice, KnockoutNeurogliaNeuronsOligodendrogliaPotassium Channels, Inwardly RectifyingSeizuresSpinal CordKcnj10 ChannelPotassium Channels, Inwardly RectifyingKir4.1 (KCNJ10)mouseneurobiologyneurodegenerationneuroscienceoligodendrocytesvisual Systemwhite matter
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.