ArticleHuman brain mapping2019
Aberrant structural-functional coupling in adult cannabis users.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Is resting-state functional connectivity altered in regular cannabis users? A systematic review of the literature.Psychopharmacology · 2022Pooled it
- Chronic cannabis use is associated with alterations in resting-state cerebellar-cortical connectivity.Psychopharmacology · 2026Article
- Alterations of Brain Structural and Functional Connectivity Networks and Its Correlations With Cognitive Function in Patients With Hypothalamic Syndrome Following Craniopharyngioma Resection.Brain and behavior · 2025Article
- The Effects of THC and Nicotine on Attention: A Narrative Review.Current topics in behavioral neurosciences · 2025Review
- Large language models can extract metadata for annotation of human neuroimaging publications.Frontiers in neuroinformatics · 2025Article
- DFC-Igloo: A dynamic functional connectome learning framework for identifying neurodevelopmental biomarkers in very preterm infants.Computer methods and programs in biomedicine · 2024Article
- White matter alterations associated with chronic cannabis use disorder: a structural network and fixel-based analysis.Translational psychiatry · 2024Article
- Chronic cannabis use associated with subcortical topological reorganization of structural connectivity in adults.Drug and alcohol dependence · 2024Article
- Longitudinal Associations Between Cannabis Use and Cognitive Impairment in a Clinical Sample of Middle-Aged Adults Using Cannabis for Medical Symptoms.Cannabis and cannabinoid research · 2024Article
- Beta-informativeness-diffusion multilayer graph embedding for brain network analysis.Frontiers in neuroscience · 2024Article
- Altered brain structural and functional connectivity in cannabis users.Scientific reports · 2023Article
- Aberrant dynamic Functional-Structural connectivity coupling of Large-scale brain networks in poststroke motor dysfunction.NeuroImage. Clinical · 2023Article
- Local structural-functional connectivity decoupling of caudate nucleus in infantile esotropia.Frontiers in neuroscience · 2022Article
- Naturalistic exploratory study of the associations of substance use on ADHD outcomes and function.BMC psychiatry · 2021Article
- Selective Aberrant Functional-Structural Coupling of Multiscale Brain Networks in Subcortical Vascular Mild Cognitive Impairment.Neuroscience bulletin · 2021Article
- Analysis of Correlation Between White Matter Changes and Functional Responses in Post-stroke Depression.Frontiers in aging neuroscience · 2021Article
- The compensatory phenomenon of the functional connectome related to pathological biomarkers in individuals with subjective cognitive decline.Translational neurodegeneration · 2020Article
- Abnormal Anatomical Rich-Club Organization and Structural-Functional Coupling in Mild Cognitive Impairment and Alzheimer's Disease.Frontiers in neurology · 2020Article
- Cannabis effects on brain structure, function, and cognition: considerations for medical uses of cannabis and its derivatives.The American journal of drug and alcohol abuse · 2019Review
- Aberrant structural-functional coupling in adult cannabis users.Human brain mapping · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Cellular studies indicate that endocannabinoid type-1 retrograde signaling plays a major role in synaptic plasticity. Disruption of these processes by delta-9-tetrahydrocannabinol (THC) could produce alterations either in structural and functional brain connectivity or in their association in cannabis (CB) users. Graph theoretic structural and functional networks were generated with diffusion tensor imaging and resting-state functional imaging in 37 current CB users and 31 healthy non-users. The primary outcome measures were coupling between structural and functional connectivity, global network characteristics, association between the coupling and network properties, and measures of rich-club organization. Structural-functional (SC-FC) coupling was globally preserved showing a positive association in current CB users. However, the users had disrupted associations between SC-FC coupling and network topological characteristics, most perturbed for shorter connections implying region-specific disruption by CB use. Rich-club analysis revealed impaired SC-FC coupling in the hippocampus and caudate of users. This study provides evidence of the abnormal SC-FC association in CB users. The effect was predominant in shorter connections of the brain network, suggesting that the impact of CB use or predispositional factors may be most apparent in local interconnections. Notably, the hippocampus and caudate specifically showed aberrant structural and functional coupling. These structures have high CB1 receptor density and may also be associated with changes in learning and habit formation that occur with chronic cannabis use.
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