Catalytic Isohypsic-Redox Sequences for the Rapid Generation of C

Craig D Smith, David Phillips, Alina Tirla, David J France

Abstract read

In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Catalytic Isohypsic-Redox Sequences for the Rapid Generation of CChemistry (Weinheim an der Bergstrasse, Germany) · 2018
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Craig D SmithWestChem School of Chemistry, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK.

David PhillipsWestChem School of Chemistry, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK.

Alina TirlaWestChem School of Chemistry, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK.

David J FranceWestChem School of Chemistry, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK.ORCID http://orcid.org/0000-0002-5409-3316

Funding

Engineering and Physical Sciences Research Council EP/I027165/1Engineering and Physical Sciences Research Council EP/J500434/1Engineering and Physical Sciences Research Council EP/K503058/1University of Glasgow

6 · The paper itself

Abstract

Cross-coupling reactions catalyzed by transition metals are among the most influential in modern synthetic chemistry. The vast majority of transition-metal-catalyzed cross-couplings rely on a catalytic cycle involving alternating oxidation and reduction of the metal center and are generally limited to forging just one type of new bond per reaction (e.g., the biaryl linkage formed during a Suzuki cross-coupling). This work presents an Isohypsic-Redox Sequence (IRS) that uses one metal to effect two catalytic cycles, thereby generating multiple new types of bonds from a single catalyst source. We show that the IRS strategy is amenable to several widely used transformations including the Suzuki-Miyaura coupling, Buchwald-Hartwig amination, and Wacker oxidation. Furthermore, each of these reactions generates value-added heterocycles with significant sp

Indexed as

heterocycleshomogeneous catalysisisohypsicpalladiumtandem catalysis

Identifiers

PMID30203869

DOI10.1002/chem.201804131

PMCPMC6391974

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.