Evidence map›Paper›PMID 30203797›Full record

ReviewChinese medical journal2018

Effect of Regulatory Network of Exosomes and microRNAs on Neurodegenerative Diseases.

Dong Li, You-Ping Li, Yun-Xiang Li, Xiao-Hua Zhu, Xiao-Gang Du, Min Zhou, Wen-Bin Li, Hong-Yan Deng

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chinese medical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. [Recent advances on the role of exosomes in neurodegenerative diseases].Se pu = Chinese journal of chromatography · 2025
    Review
  5. Cell-cell communication: new insights and clinical implications.Signal transduction and targeted therapy · 2024
    Review
  6. Review
  7. The role of exosomes in pathogenesis and the therapeutic efficacy of mesenchymal stem cell-derived exosomes against Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dong LiDepartment of Environmental Engineering, College of Environmental Science and Engineering, China West Normal University, Nanchong, Sichuan 637009; Department of Engineering and Applied Biology, College of Life Science, Sichuan Agricultural University, Ya'an, Sichuan 625014, China.
You-Ping LiDepartment of Environmental Engineering, College of Environmental Science and Engineering, China West Normal University, Nanchong, Sichuan 637009, China.
Yun-Xiang LiDepartment of Environmental Engineering, College of Environmental Science and Engineering, China West Normal University, Nanchong, Sichuan 637009, China.
Xiao-Hua ZhuDepartment of Environmental Engineering, College of Environmental Science and Engineering, China West Normal University, Nanchong, Sichuan 637009; Department of Environmental Geology, College of Environmental and Civil Engineering, Chengdu University of Technology, Chengdu, Sichuan 610059, China.
Xiao-Gang DuDepartment of Engineering and Applied Biology, College of Life Science, Sichuan Agricultural University, Ya'an, Sichuan 625014, China.
Min ZhouDepartment of Engineering and Applied Biology, College of Life Science, Sichuan Agricultural University, Ya'an, Sichuan 625014, China.
Wen-Bin LiDepartment of Environmental Engineering, College of Environmental Science and Engineering, China West Normal University, Nanchong, Sichuan 637009, China.
Hong-Yan DengDepartment of Environmental Engineering, College of Environmental Science and Engineering, China West Normal University, Nanchong, Sichuan 637009, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveA comprehensive review of the network regulation of exosomes and microRNAs (miRNAs) in neurodegenerative diseases was done, centering on the mechanism of the formation of exosomes and miRNAs and the sorting mechanism of exosomal miRNAs, with the aim to provide a theoretical basis in the search of biomarkers and the treatment of neurodegenerative diseases. DATA SOURCES: The comprehensive search used online literature databases including NCBI PubMed, Web of Science, Google Scholar, and Baidu Scholar. STUDY SELECTION: The study selection was based on the following keywords: exosomes, miRNAs, central nervous system (CNS), and neurodegenerative diseases. The time limit for literature retrieval was from the year 2000 to 2018, with language restriction in English. Relevant articles were carefully reviewed, with no exclusions applied to study design and publication type.

resultsExosomes are the smallest nanoscale membranous microvesicles secreted by cells and contain important miRNAs, among other rich contents. In the CNS, exosomes can transport amyloid β-protein, α-synuclein, Huntington-associated protein 1, and superoxide dismutase I to other cells. These events relieve the abnormal accumulation of proteins and aggravating neurological diseases. In some neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, miRNAs are pathologically altered as an inexorable course, suggesting that miRNAs may contribute neurodegeneration. Exosomes and miRNAs form a network to regulate the homeostasis of the CNS, both synergistically and individually.

conclusionThe network of exosomes and miRNAs that regulates CNS homeostasis is a promising biomarker for the diagnosis and treatment of neurodegenerative diseases.

Indexed as

ExosomesMicroRNAsAlzheimer DiseaseAmyloid beta-PeptidesHumansNeurodegenerative DiseasesAmyloid beta-PeptidesMicroRNAsCentral Nervous SystemExosomesmicroRNAsNeurodegenerative Diseases

Identifiers

PMID30203797
PMCPMC6144844

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.