Evidence map›Paper›PMID 30203722›Full record

ArticleTissue engineering. Part A2019

A Functional Tissue-Engineered Synovium Model to Study Osteoarthritis Progression and Treatment.

Robert M Stefani, Saiti S Halder, Eben G Estell, Andy J Lee, Amy M Silverstein, Evie Sobczak, Nadeen O Chahine, Gerard A Ateshian, Roshan P Shah, Clark T Hung

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue engineering. Part A, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Osteoarthritis and cartilage open · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Toward Development of a Diabetic Synovium Culture Model.Frontiers in bioengineering and biotechnology · 2022
    Article
  15. Typical response of CD14Frontiers in medicine · 2022
    Article
  16. Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Robert M Stefani1 Department of Biomedical Engineering, Columbia University , New York, New York.
Saiti S Halder1 Department of Biomedical Engineering, Columbia University , New York, New York.
Eben G Estell1 Department of Biomedical Engineering, Columbia University , New York, New York.
Andy J Lee1 Department of Biomedical Engineering, Columbia University , New York, New York.
Amy M Silverstein1 Department of Biomedical Engineering, Columbia University , New York, New York.
Evie Sobczak1 Department of Biomedical Engineering, Columbia University , New York, New York.
Nadeen O Chahine1 Department of Biomedical Engineering, Columbia University , New York, New York.
Gerard A Ateshian1 Department of Biomedical Engineering, Columbia University , New York, New York.
Roshan P Shah2 Department of Orthopedic Surgery, Columbia University , New York, New York.
Clark T Hung1 Department of Biomedical Engineering, Columbia University , New York, New York.
Columbia University · US

Funding

Incorporation of Dexamethasone Delivery within Engineered CartilageR01AR068133 · NIAMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HUNG, CLARK T. · 2016 to 2021
$2.8M
Mechanobiology of Inflammation in the Intervertebral DiscR01AR069668 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHAHINE, NADEEN O. · 2016 to 2021
$2.0M
Multidisciplinary Engineering Training in Musculoskeletal ResearchT32AR059038 · NIAMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI ATESHIAN, GERARD A. · 2011 to 2015
$1.3M
NIAMS NIH HHS R01 AR068133NIAMS NIH HHS R01 AR069668NIAMS NIH HHS T32 AR059038
6 · The paper itself

Abstract

impact statementThe synovium envelops the diarthrodial joint and plays a key regulatory role in defining the composition of the synovial fluid through filtration and biosynthesis of critical boundary lubricants. Synovium changes often precede cartilage damage in osteoarthritis. We describe a novel

Indexed as

Adrenal Cortex HormonesCartilage, ArticularCytokinesDexamethasoneHumansInterleukin-1OsteoarthritisSynovial FluidSynovial MembraneTissue EngineeringAdrenal Cortex HormonesCytokinesDexamethasoneInterleukin-1modelsosteoarthritissolute transportsynovium

Identifiers

PMID30203722
PMCPMC6482911
OpenAlexW2891625803

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.