Evidence map›Paper›PMID 30203705›Full record

ReviewJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2018

Variability of functional outcome measures used in animal models of stroke and vascular cognitive impairment - a review of contemporary studies.

Tuuli M Hietamies, Caroline Ostrowski, Zhong Pei, Luyang Feng, Christopher McCabe, Lorraine M Work, Terence J Quinn

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 5 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 5 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. UK consensus on pre-clinical vascular cognitive impairment functional outcomes assessment: Questionnaire and workshop proceedings.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Tuuli M Hietamies1 Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences; University of Glasgow, Glasgow, UK.
Caroline Ostrowski1 Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences; University of Glasgow, Glasgow, UK.
Zhong Pei2 Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou Shi, Guangdong Sheng, China.
Luyang Feng2 Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou Shi, Guangdong Sheng, China.
Christopher McCabe3 Institute of Neuroscience & Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.ORCID 0000-0003-3111-031X
Lorraine M Work1 Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences; University of Glasgow, Glasgow, UK.ORCID 0000-0002-6462-4109
Terence J Quinn1 Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences; University of Glasgow, Glasgow, UK.ORCID 0000-0003-1401-0181
University of Glasgow · GBSun Yat-sen University · CN

Funding

Chief Scientist Office
6 · The paper itself

Abstract

Despite promising preclinical data, few novel stroke therapies have shown efficacy in man. Efforts to improve standards in conduct and reporting of preclinical research are ongoing. In clinical trials, inconsistency in outcome measures led to regulatory agencies and funders mandating use of a core set of functional outcomes. Our aim was to describe functional outcome measures in preclinical stroke and vascular cognitive impairment (VCI) studies. From 14 high impact journals (January 2005-December 2015 inclusive), 91,956 papers were screened with 1302 full texts analyzed for stroke (ischemic and hemorrhagic) and 56 for VCI studies. In total, 636 (49%) stroke and 37 (66%) VCI papers reported functional outcome measures. There were 74 different functional assessments reported in stroke and 20 in VCI studies. Neurological deficit scores (74%) and Morris water maze (60%) were most commonly used in stroke and VCI, respectively. However, inconsistencies in methods used to assess and score recovery were noted. Neurological and behavioural functional outcome measures are increasingly used in preclinical stroke or VCI studies; however, there is substantial variation in methods. A strict standardized outcome set may not be suitable for translational work, but greater consistency in choice, application and reporting of outcomes may improve the science.

Indexed as

Dementia, VascularDisease Models, AnimalRecovery of FunctionStrokeAnimalsfunctional outcome measurehemorrhagic strokemiddle cerebral artery occlusionRodentvascular cognitive impairment

Identifiers

PMID30203705
PMCPMC6259321
OpenAlexW2890748880

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.