Evidence map›Paper›PMID 30203532›Full record

ArticleBiopolymers2018

Spectroscopic and metal binding properties of a de novo metalloprotein binding a tetrazinc cluster.

Marco Chino, Shao-Qing Zhang, Fabio Pirro, Linda Leone, Ornella Maglio, Angela Lombardi, William F DeGrado

Open access · greenAbstract read
In one paragraph

Article in Biopolymers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. De novo metalloprotein design.Nature reviews. Chemistry · 2022
    Article
  6. Review
  7. Allosteric cooperation in a de novo-designed two-domain protein.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  8. Article
  9. Quarterly reviews of biophysics · 2020
    Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Marco ChinoDepartment of Chemical Sciences, University of Napoli "Federico II,", Via Cintia, 46, Napoli, 80126, Italy.
Shao-Qing ZhangDepartment of Pharmaceutical Chemistry and the Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California.
Fabio PirroDepartment of Chemical Sciences, University of Napoli "Federico II,", Via Cintia, 46, Napoli, 80126, Italy.
Linda LeoneDepartment of Chemical Sciences, University of Napoli "Federico II,", Via Cintia, 46, Napoli, 80126, Italy.
Ornella MaglioDepartment of Chemical Sciences, University of Napoli "Federico II,", Via Cintia, 46, Napoli, 80126, Italy.
Angela LombardiDepartment of Chemical Sciences, University of Napoli "Federico II,", Via Cintia, 46, Napoli, 80126, Italy.ORCID https://orcid.org/0000-0002-2013-3009
William F DeGradoDepartment of Pharmaceutical Chemistry and the Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California.ORCID https://orcid.org/0000-0003-4745-263X
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli · ITUniversity of California, San Francisco · USUniversity of the Sciences · US

Funding

Deciphering the relationship between structure, dynamics and function in helical bundle proteinsR35GM122603 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WILLIAM DEGRADO · 2017 to 2026
$7.1M
NIGMS NIH HHS R35 GM122603NIH grant R35GM122603 (WFD)NSF CHE1413295Research Department of Campania Region (STRAIN Project, POR FSE 2007/2013) B25B0900000000 (MC)Università degli Studi di Napoli Federico II for mobility grants (WFD, MC)
6 · The paper itself

Abstract

De novo design provides an attractive approach, which allows one to test and refine the principles guiding metalloproteins in defining the geometry and reactivity of their metal ion cofactors. Although impressive progress has been made in designing proteins that bind transition metal ions including iron-sulfur clusters, the design of tetranuclear clusters with oxygen-rich environments remains in its infancy. In previous work, we described the design of homotetrameric four-helix bundles that bind tetra-Zn

Indexed as

Amino Acid SequenceCircular DichroismMagnetic Resonance SpectroscopyMetalloproteinsPeptidesSolutionsZincMetalloproteinsPeptidesSolutionsZinccoiled coilsde novo protein designfour-helix bundlesmultinuclear transition metal ion clustersspectroscopic characterization

Identifiers

PMID30203532
PMCPMC6218314
OpenAlexW2891999158

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.