ArticleJournal of clinical hypertension (Greenwich, Conn.)2018
Kidney protective effects of baroreflex activation therapy in patients with resistant hypertension.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Neurocardiology: translational advancements and potential.The Journal of physiology · 2025Review
- Successful baroreflex activation therapy in a case of therapy-resistant renovascular hypertension.Clinical research in cardiology : official journal of the German Cardiac Society · 2023Article
- Impact of medication adherence on the efficacy of Baroreflex activation therapy.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Hypertension in chronic kidney disease: What lies behind the scene.Frontiers in pharmacology · 2022Review
- Eligibility for Baroreflex Activation Therapy and medication adherence in patients with apparently resistant hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Implant-Mediated Therapy of Arterial Hypertension.Current hypertension reports · 2020Review
- One approach to circulation and blood flow in the critical care unit.World journal of critical care medicine · 2019Review
- Kidney protective effects of baroreflex activation therapy in patients with resistant hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Baroreflex activation therapy (BAT) is approved for the treatment of resistant hypertension. In addition to blood pressure (BP) reduction, pilot studies suggested several organoprotective effects of BAT. Thirty-two patients with resistant hypertension were prospectively treated with BAT. Besides office BP and 24-hour ambulatory BP (ABP) measurements, detection of a urinary proteome-based classifier (CKD273), which has been shown to predict chronic kidney disease (CKD) progression, was carried out at baseline and after 6 months of BAT. Office BP significantly decreased from 170 ± 25/90 ± 18 to 149 ± 29/82 ± 18 mm Hg. Analysis of CKD273 score and eGFR with CKD-EPI equation at baseline revealed strong correlation (r = 0.568, P < 0.001). After 6 months of BAT, there was no significant change in CKD273 score (-0.061 [95% CI: -0.262 to 0.140], P = 0.601). However, by stratification of the data regarding ABP response, there was a statistically significant (P = 0.0113) reduction in the CKD273 score from a mean of 0.161 [95% CI: -0.093 to 0.414] to -0.346 [95% CI: -0.632 to -0.060] after BAT in patients with systolic ABP decrease of ≥5 mm Hg. These data emphasized potential nephroprotective effects of BAT in patients with sufficient BP response.
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