Evidence map›Paper›PMID 30203465›Full record

ArticlePhysiological reports2018

Replicating measurements of total hemoglobin mass (tHb-mass) within a single day: precision of measurement; feasibility and safety of using oxygen to expedite carbon monoxide clearance.

James O M Plumb, Shriya Kumar, James Otto, Walter Schmidt, Toby Richards, Hugh E Montgomery, Mike P W Grocott

Abstract readEvaluation Study
In one paragraph

Article in Physiological reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. A simple and novel equation to estimate the degree of bleeding in haemorrhagic shock: mathematical derivation and preliminaryThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2022
    Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

James O M PlumbRespiratory and Critical Care Research Area, NIHR Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, University of Southampton, Southampton, United Kingdom.
Shriya KumarAnaesthesia and Critical Care Research Unit, University Hospital Southampton NHSFT, Southampton, United Kingdom.
James OttoShackleton Department of Anaesthesia, University Hospital Southampton NHSFT, Southampton, United Kingdom.
Walter SchmidtDepartment of Sports Medicine/Sports Physiology, University of Bayreuth, Bayreuth, Germany.
Toby RichardsDivision of Surgery and Interventional Science, University College London, London, United Kingdom.
Hugh E MontgomeryCentre for Human Health and Performance, Institute of Sport, Exercise and Health, University College London, NIHR University College London Hospitals Biomedical Research Centre, London, United Kingdom.
Mike P W GrocottRespiratory and Critical Care Research Area, NIHR Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, University of Southampton, Southampton, United Kingdom.

Funding

Department of Health 10/104/06Wellcome Trust
6 · The paper itself

Abstract

Hemoglobin concentration ([Hb]) is a function of total hemoglobin mass (tHb-mass) and plasma volume. [Hb] may fall by dilution due to plasma volume expansion and changes in the perioperative period may therefore correlate poorly with blood loss. A simple, reliable, repeatable way to measure plasma volume and tHb-mass would have substantial clinical utility. The "optimized carbon monoxide re-breathing method" (oCOR) meets these criteria. However, it is recommended that a minimum of 12 h (when breathing room air) is left between repeat measurements. Twenty-four subjects underwent 3 days of testing. Two oCOR tests were performed (T1 and T2), 3 h apart, with a different CO clearance method employed between tests aiming to keep the carboxyhemoglobin level below 10%. The primary aim was to ascertain whether tHb-mass testing could be safely repeated within 3 h if carboxyhemoglobin levels were actively reduced by breathing supplemental oxygen (PROC

Indexed as

Erythrocyte IndicesAdultCarbon MonoxideCarboxyhemoglobinExerciseFemaleHemoglobinometryHumansMaleMetabolic Clearance RateOxygenPlasma VolumeReproducibility of ResultsCarbon MonoxideCarboxyhemoglobinOxygenBlood volumeoptimized carbon monoxide re-breathingplasma volumered cell volumetotal hemoglobin mass (tHb-mass)

Identifiers

PMID30203465
PMCPMC6131726

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.