ReviewThe journal of headache and pain2018
Myofascial trigger points in migraine and tension-type headache.
Review in The journal of headache and pain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05340049 (Early Craniosacral Therapy Improves Infant Neurodevelopment in Apparently Healthy Children.), which is not on this map. Cited by 80 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Craniosacral Therapy Improves Infant Neurodevelopment in Apparently Healthy Children.
Who cites it
80 citing papers in PubMed, 4 syntheses or guidelines pooled it, 190 citations in OpenAlex.
- Exploring Proximal and Distal Ultrasound-Guided Greater Occipital Nerve Block Approaches in Migraine: A Systematic Review and Meta-Analysis.Pain practice : the official journal of World Institute of Pain · 2026Pooled it
- Myofascial Release for the Treatment of Tension-Type, Cervicogenic Headache or Migraine: A Systematic Review and Meta-Analysis.Pain research & management · 2024Pooled it
- Effectiveness of intraoral splints in the treatment of migraine and tension-type headache: A systematic review.Clinical and experimental dental research · 2023Pooled it
- Are Morphometric Alterations of the Deep Neck Muscles Related to Primary Headache Disorders? A Systematic Review.Sensors (Basel, Switzerland) · 2023Pooled it
- Effects of kinesiotaping combined with physical therapy in patients with migraine-associated neck pain: a randomized controlled study.BMC musculoskeletal disorders · 2025Trial
- Efficacy of temporo-parietal fascia trigger point release in the management of tension-type headache: a single-blinded RCT.Pain management · 2025Trial
- Myofascial trigger points therapy increases neck mobility and reduces headache pain in migraine patients - pilot study.BMC musculoskeletal disorders · 2025Trial
- Effects of Repeated Injection of 1% Lidocaine vs. Radial Extracorporeal Shock Wave Therapy for Treating Myofascial Trigger Points: A Randomized Controlled Trial.Medicina (Kaunas, Lithuania) · 2022Trial
- The influence of myofascial release on pain and selected indicators of flat foot in adults: a controlled randomized trial.Scientific reports · 2022Trial
- Ultrasound-Guided Inactivation of Trigger Points Combined with Muscle Fascia Stripping by Liquid Knife in Treatment of Postherpetic Neuralgia Complicated with Abdominal Myofascial Pain Syndrome: A Prospective and Controlled Clinical Study.Pain research & management · 2020Trial
- Detecting Intervention-Specific Change in Soft Tissue Mobility Aligned with Regional Pain Through Optically Measured Skin Surface Strains.Annals of biomedical engineering · 2026Article
- Adapting Tension-Type Headache to the International Association for the Study of Pain (IASP) Taxonomy: A Conceptual Proposal.Biomedicines · 2026Review
- Ultrasonographic masseter and temporalis thickness in tension-type headache.Acta neurologica Belgica · 2026Article
- Texture analysis on muscle T2 maps can reveal changes in upper trapezius muscles related to primary headache disorders.Scientific reports · 2026Article
- Effects of Spinal Manipulation and Dry Needling on Headache and Migraine: A Systematic Review of Randomized Controlled Trials.Journal of clinical medicine · 2026Review
- Combined ultrasound-guided C2 DRG pulsed radiofrequency and suboccipital myofascial plane block for cervicogenic headache: a retrospective study.Frontiers in pain research (Lausanne, Switzerland) · 2026Article
- Association Between the Frailty Index and Self-Reported Headache in Middle-Aged and Older Chinese Adults: An Analysis of the China Health and Retirement Longitudinal Study.Pain research & management · 2026Article
- Causal proteomic insights into drug target discovery for tension-type headache.The journal of headache and pain · 2025Article
- Strain-based biomarkers at the skin surface differentiate asymmetries in soft tissue mobility associated with myofascial pain.Journal of the mechanical behavior of biomedical materials · 2025Article
- Review
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA myofascial trigger point is defined as a hyperirritable spot in skeletal muscle that is associated with a hypersensitive palpable nodule in a taut band. It has been suggested that myofascial trigger points take part in chronic pain conditions including primary headache disorders. The aim of this narrative review is to present an overview of the current imaging modalities used for the detection of myofascial trigger points and to review studies of myofascial trigger points in migraine and tension-type headache.
findingsDifferent modalities have been used to assess myofascial trigger points including ultrasound, microdialysis, electromyography, infrared thermography, and magnetic resonance imaging. Ultrasound is the most promising of these modalities and may be used to identify MTrPs if specific methods are used, but there is no precise description of a gold standard using these techniques, and they have yet to be evaluated in headache patients. Active myofascial trigger points are prevalent in migraine patients. Manual palpation can trigger migraine attacks. All intervention studies aiming at trigger points are positive, but this needs to be further verified in placebo-controlled environments. These findings may imply a causal bottom-up association, but studies of migraine patients with comorbid fibromyalgia syndrome suggest otherwise. Whether myofascial trigger points contribute to an increased migraine burden in terms of frequency and intensity is unclear. Active myofascial trigger points are prevalent in tension-type headache coherent with the hypothesis that peripheral mechanisms are involved in the pathophysiology of this headache disorder. Active myofascial trigger points in pericranial muscles in tension-type headache patients are correlated with generalized lower pain pressure thresholds indicating they may contribute to a central sensitization. However, the number of active myofascial trigger points is higher in adults compared with adolescents regardless of no significant association with headache parameters. This suggests myofascial trigger points are accumulated over time as a consequence of TTH rather than contributing to the pathophysiology.
conclusionsMyofascial trigger points are prevalent in both migraine and tension-type headache, but the role they play in the pathophysiology of each disorder and to which degree is unclarified. In the future, ultrasound elastography may be an acceptable diagnostic test.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.