Evidence map›Paper›PMID 30203361›Full record

ArticleVirus genes2018

Phylogenetic analysis of two genotype 3 Hepatitis E viruses from wild boar, Italy.

Luca De Sabato, Gabriele Vaccari, Philippe Lemey, Maria Grazia Amoroso, Giovanna Fusco, Giovanni Ianiro, Ilaria Di Bartolo

Abstract read
PubMed Publisher
In one paragraph

Article in Virus genes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Luca De SabatoDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161, Rome, Italy.
Gabriele VaccariDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161, Rome, Italy. gabriele.vaccari@iss.it.ORCID http://orcid.org/0000-0003-0215-3521
Philippe LemeyDepartment of Microbiology and Immunology, Rega Institute, KU Leuven - University of Leuven, Herestraat 49, 3000, Louvain, Belgium.
Maria Grazia AmorosoDepartment of Animal Health, Istituto Zooprofilattico del Mezzogiorno, Via Salute, 2, 80055, Portici, NA, Italy.
Giovanna FuscoDepartment of Animal Health, Istituto Zooprofilattico del Mezzogiorno, Via Salute, 2, 80055, Portici, NA, Italy.
Giovanni IaniroDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161, Rome, Italy.
Ilaria Di BartoloDepartment of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161, Rome, Italy.
Istituto Superiore di Sanità · ITIstituto Zooprofilattico Sperimentale del Mezzogiorno · ITRega Institute for Medical Research · BE

Funding

European Union's Seventh Framework Programme for Research, Technological Development and Demonstration 278433
6 · The paper itself

Abstract

The complete and near-complete genome sequences (7206 nt and 7229 nt) of two wild boar HEV strains detected in Southern Italy were obtained by the next generation sequencing. Phylogenetic analysis and p distance comparisons of one of the strains with HEV-3 reference subtype strains confirmed the detection of a subtype 3i (p distance = 0.110) strain in wild boar, never detected in Italy either in wild boar or pigs. The sequence of the second strain was not classifiable in any of the subtypes defined to date, showing a p distance > 0.138 and a low nucleotide identity with all HEV reference strains. The virus may represent a novel subtype, with a low relationship to other strains of genotype 3 detected in wild boar, pigs, or humans in Europe. This result suggests the circulation in Italy of an emerging or uncommon HEV strain. Sequencing followed by phylogenetic analyses of the complete HEV coding regions are important tools for understanding the evolutionary and epidemiological dynamics underlying the wide genetic diversity of HEV strains.

Indexed as

GenotypePhylogenyAnimalsGenome, ViralHepatitis EHepatitis E virusItalySus scrofaSwineSwine DiseasesFull genomeHepatitis E virusHEV-3Next generation sequencingSubtypeWild boar

Identifiers

PMID30203361
OpenAlexW2889960373

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.