ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2019
Oral and dental alterations and growth disruption following chemotherapy in long-term survivors of childhood malignancies.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Best clinical practise guidance for oral health care management of long-term childhood cancer survivors (CCS): an EAPD policy document.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2025Guideline
- Salivary Secretory Immunoglobulin A as a Candidate Biomarker of Oral Mucosal Vulnerability in Paediatric Acute Lymphoblastic Leukaemia: A Prospective Pilot Cohort Study.Children (Basel, Switzerland) · 2026Article
- Dental caries in childhood cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Late Oral Complications in Childhood Cancer Survivors: Implications for Pediatric Dentistry and Survivorship Care.Children (Basel, Switzerland) · 2026Review
- Orthodontic treatment outcomes and safety for secondary dentofacial deformities after childhood cancer therapy: a systematic review and meta-analysis.American journal of cancer research · 2026Review
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- Temporomandibular Joint and Dental Complications in Long-Term Survivors of Children with Leukemia after Chemoradiotherapy and Stem Cell Transplantation.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2025Article
- Antineoplastic therapy is an independent risk factor for dental caries in childhood cancer patients: a retrospective cohort study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
- Review
- Antineoplastic therapy in childhood cancer patients presents a negative impact in the periodontal tissues: a cohort study.Clinical oral investigations · 2023Article
- Oral Manifestations: A Warning-Sign in Children with Hematological Disease Acute Lymphocytic Leukemia.Hematology reports · 2023Review
- Dental caries and dental developmental defects as adverse effects of antineoplastic treatment in childhood cancer survivors.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2023Article
- Oral and dental late effects in long-term survivors of childhood embryonal brain tumors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- The prevalence of dental developmental anomalies among childhood cancer survivors according to types of anticancer treatment.Scientific reports · 2022Article
- Article
- Factors and Mechanisms Involved in Acquired Developmental Defects of Enamel: A Scoping Review.Frontiers in pediatrics · 2022Article
- Cancer survivors present significantly lower long-term stability of orthodontic treatment: a prospective case-control study.European journal of orthodontics · 2021Article
- Article
- Inhibition of caspase-3-mediated GSDME-derived pyroptosis aids in noncancerous tissue protection of squamous cell carcinoma patients during cisplatin-based chemotherapy.American journal of cancer research · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMore attention has been focused on the long-term side effects of treatment protocols since impressive advances in childhood cancer treatment have resulted in a growing population of patients. The purpose of this study was to investigate the disturbances of dento-facial development in children who were long-term survivors of childhood malignancies.
methodsFifty-three children (mean age, 10 years + 4 months) in long-term remission underwent oral/dental and radiographic examinations after completion of therapy. Crown and root malformations, gingival/periodontal status, enamel defects, discolorations, decayed and unerupted teeth, premature apexifications, agenesis, maximal interincisal opening and lateral movement of jaws, and soft tissue abnormalities were noted. Caries were evaluated by the decayed-missing-filled teeth (DMFT) index. Forty healthy children (mean age, 12 years + 4 months) belonging to the same age group and socioeconomic community were served as controls. All participants in the study were evaluated in terms of craniofacial development.
resultsThe data of the study showed that higher prevalence of root malformation, unerupted teeth, and enamel hypoplasia were detected as a consequence of childhood cancer and/or antineoplastic therapy. Although no differences of craniofacial growth and development were observed between groups (P > 0.05), plaque and gingival index scores were statistically higher in the study group (P < 0.05).
conclusionA range of variations in dental structures is recognized as a side effect of childhood cancer therapy in long-term survivors of pediatric malignancies that may affect their quality of life.
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