Evidence map›Paper›PMID 30203336›Full record

ArticleEuropean journal of epidemiology2018

Understanding the relationship between cognition and death: a within cohort examination of cognitive measures and mortality.

Shabina A Hayat, Robert Luben, Nichola Dalzell, Stephanie Moore, Eef Hogervorst, Fiona E Matthews, Nick Wareham, Carol Brayne, Kay-Tee Khaw

Abstract read
In one paragraph

Article in European journal of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Prediction of cognitive outcome and progression to dementia using ω6-PUFA/ω3-PUFA ratio.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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  11. Incremental Healthcare Costs of Dementia and Cognitive Impairment in Community-Dwelling Older Adults: A Prospective Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shabina A HayatDepartment of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK. sah63@cam.ac.uk.ORCID http://orcid.org/0000-0001-9068-8723
Robert LubenDepartment of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK.
Nichola DalzellDepartment of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK.
Stephanie MooreDepartment of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK.
Eef HogervorstApplied Cognitive Research Group, Loughborough University, National Centre for Sports and Exercise Medicine, Loughborough, UK.
Fiona E MatthewsFaculty of Medicine, Institute of Health and Society, Newcastle University, Newcastle, UK.
Nick WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Carol BrayneDepartment of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK.
Kay-Tee KhawDepartment of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK.

Funding

Cancer Research UK C864/ A2883Cancer Research UK C864/A8257Medical Research Council G0401527Medical Research Council G1000143Medical Research Council G9502233Medical Research Council MC_U105292687Medical Research Council MC_UU_12015/1Medical Research Council MR/N003284/1Research into Ageing 262
6 · The paper itself

Abstract

Despite several studies demonstrating an independent and inverse association between cognition and mortality, the nature of this association still remains unclear. To examine the association of cognition and mortality after accounting for sociodemographic, health and lifestyle factors and to explore both test and population characteristics influencing this relationship. In a population based cohort of 8585 men and women aged 48-92 years, who had cognitive assessments in 2006-2011 and were followed up till 2016 for mortality, we examined the relationship between individual cognitive tests as well as a global cognition score to compare their ability in predicting mortality and whether these differed by population characteristics. Risk of death was estimated using Cox proportional hazard regression models including sociodemographic, lifestyle and health variables, and self-reported comorbidities, as covariates in the models. Poor cognitive performance (bottom quartile of combined cognition score) was associated with higher risk of mortality, Hazard Ratio = 1.32 (95% Confidence Interval 1.09, 1.60); individual cognitive tests varied in their mortality associations and also performed differently in middle-age and older age groups. Poor cognitive performance is independently associated with higher mortality. This association is observed for global cognition and for specific cognitive abilities. Associations vary depending on the cognitive test (and domain) as well as population characteristics, namely age and education.

Indexed as

MortalityAgedAged, 80 and overAgingCognitionCognition DisordersCognitive AgingCohort StudiesFemaleHumansMaleMiddle AgedRiskUnited KingdomCognitive functionEpidemiologyMortalityPopulation

Identifiers

PMID30203336
PMCPMC6208995

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.