Evidence map›Paper›PMID 30203250›Full record

ReviewCurrent osteoporosis reports2018

Carbon Nanomaterials for Treating Osteoporotic Vertebral Fractures.

Jancineide Oliveira de Carvalho, Francilio de Carvalho Oliveira, Sérgio Antonio Pereira Freitas, Liana Martha Soares, Rita de Cássia Barros Lima, Licia de Sousa Gonçalves, Thomas Jay Webster, Fernanda Roberta Marciano, Anderson Oliveira Lobo

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current osteoporosis reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jancineide Oliveira de CarvalhoInstituto de Ciência e Tecnologia, Universidade Brasil, Rua Carolina da Fonseca, 584, Bairro Itaquera, São Paulo, 08230-030, Brazil.
Francilio de Carvalho OliveiraInstituto de Ciência e Tecnologia, Universidade Brasil, Rua Carolina da Fonseca, 584, Bairro Itaquera, São Paulo, 08230-030, Brazil.
Sérgio Antonio Pereira FreitasCentro Universitário Uninovafapi, Rua Vitorino Orthiges Fernandes, n 6123, Bairro Uruguai, Teresina, Piauí, 64073-505, Brazil.
Liana Martha SoaresHospital Universitário de Teresina, Campus Universitário Ministro Petrônio Portela, SG 07, s/n - Ininga, Teresina, Piauí, 64049-550, Brazil.
Rita de Cássia Barros LimaCentro Universitário Uninovafapi, Rua Vitorino Orthiges Fernandes, n 6123, Bairro Uruguai, Teresina, Piauí, 64073-505, Brazil.
Licia de Sousa GonçalvesCentro Universitário Uninovafapi, Rua Vitorino Orthiges Fernandes, n 6123, Bairro Uruguai, Teresina, Piauí, 64073-505, Brazil.
Thomas Jay WebsterNanomedicine Laboratory, Department of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA.
Fernanda Roberta MarcianoInstituto de Ciência e Tecnologia, Universidade Brasil, Rua Carolina da Fonseca, 584, Bairro Itaquera, São Paulo, 08230-030, Brazil.
Anderson Oliveira LoboInstituto de Ciência e Tecnologia, Universidade Brasil, Rua Carolina da Fonseca, 584, Bairro Itaquera, São Paulo, 08230-030, Brazil. aolobo@pq.cnpq.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewTo identify the use of carbon nanomaterials in bone regeneration and present new data on the regenerative capacity of bone tissue in osteopenic rats treated with graphene nanoribbons (GNRs). RECENT

findingsThe results show that the physical and chemical properties of the nanomaterials are suitable for the fabrication of scaffolds intended for bone regeneration. The in vitro tests suggested a non-toxicity of the GNRs as well as improved biocompatibility and bone mineralization activity. Here, for the first time, we evaluated the potential of GNRs in remodeling and repairing bone defects in osteoporotic animal models in vivo. Interestingly, bone mineralization and the initiation of the remodeling cycle by osteoclasts/osteoblasts were observed after the implantation of GNRs, thus implying healthy bone remodeling when using GNRs. This study, therefore, has opened our perspectives and certainly calls for more attention to the use of carbon nanomaterials for a wide range of osteoporosis applications.

Indexed as

Bone RegenerationGraphiteNanotubes, CarbonTissue ScaffoldsAnimalsBiocompatible MaterialsBone RemodelingCarbonHumansOsteoblastsOsteoclastsOsteoporotic FracturesRatsSpinal FracturesBiocompatible MaterialsCarbonGraphiteNanotubes, CarbonBiomineralizationGraphene nanoribbonsHistological analysisOophorectomyOsteoporosis

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.