ReviewCurrent osteoporosis reports2018
Using Mendelian Randomization to Decipher Mechanisms of Bone Disease.
Review in Current osteoporosis reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Mendelian randomization study reveals the causal effect of sex hormone binding globulin on osteoporosis.BMC musculoskeletal disorders · 2025Article
- Article
- Genetic and causal relationship between chronic gastrointestinal diseases and erectile dysfunction: a Mendelian randomization study.Frontiers in medicine · 2024Article
- Causal roles of circulating cytokines in sarcopenia-related traits: a Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Is there a causal relationship between resistin levels and bone mineral density, fracture occurrence? A mendelian randomization study.PloS one · 2024Article
- Health Effects of Vitamin D Supplementation: Lessons Learned From Randomized Controlled Trials and Mendelian Randomization Studies.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Review
- The causal relationship between autoimmune diseases and osteoporosis: a study based on Mendelian randomization.Frontiers in endocrinology · 2023Article
- Mendelian randomization analysis does not reveal a causal influence of mental diseases on osteoporosis.Frontiers in endocrinology · 2023Observational
- A Guide for Understanding and Designing Mendelian Randomization Studies in the Musculoskeletal Field.JBMR plus · 2022Review
- The Gut Microbiome: a New Frontier in Musculoskeletal Research.Current osteoporosis reports · 2021Review
- Twelve years of GWAS discoveries for osteoporosis and related traits: advances, challenges and applications.Bone research · 2021Review
- Perspective of the GEMSTONE Consortium on Current and Future Approaches to Functional Validation for Skeletal Genetic Disease Using Cellular, Molecular and Animal-Modeling Techniques.Frontiers in endocrinology · 2021Review
- Article
- Mendelian randomization study of inflammatory bowel disease and bone mineral density.BMC medicine · 2020Article
- Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review).Journal of clinical medicine · 2020Review
- Genetic Pleiotropy of Bone-Related Phenotypes: Insights from Osteoporosis.Current osteoporosis reports · 2020Review
- Genomic Medicine: Lessons Learned From Monogenic and Complex Bone Disorders.Frontiers in endocrinology · 2020Review
- Opportunities and Challenges in Functional Genomics Research in Osteoporosis: Report From a Workshop Held by the Causes Working Group of the Osteoporosis and Bone Research Academy of the Royal Osteoporosis Society on October 5th 2020.Frontiers in endocrinology · 2020Review
- Recent Advances in the Genetics of Fractures in Osteoporosis.Frontiers in endocrinology · 2019Review
- Use of Mendelian Randomization to Examine Causal Inference in Osteoporosis.Frontiers in endocrinology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
purpose of reviewThis review summarizes the basic principles of Mendelian randomization (MR) and provides evidence for the causal effect of multiple modifiable factors on bone outcomes. RECENT
findingsSeveral studies using MR approach have provided support for the causal effect of obesity on bone mineral density (BMD). Strikingly, studies have failed to prove a causal association between elevated 25(OH) D concentrations and higher BMD in community-dwelling individuals. The MR approach has been successfully used to evaluate multiple factors related to bone mineral density variation and/or fracture risk. The MR approach avoids some of the classical observational study limitations and provides more robust causal evidence, ensuring bigger success of the clinical trials. The selection of interventions based on genetic evidence could have a substantial impact on clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.