ArticleRadiation and environmental biophysics2018
Gold-coated iron oxide nanoparticles trigger apoptosis in the process of thermo-radiotherapy of U87-MG human glioma cells.
Article in Radiation and environmental biophysics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Application of magnetic resonance spectroscopy (MRS) in photo-thermal therapy response of U87-MG human glioma cells with gold-coated iron oxide nanoparticles: an in vivo study.Magma (New York, N.Y.) · 2026Article
- Thermoradiotherapy reverses proliferation, metastasis, and anoikis resistance in glioblastoma through ITGA5-PI3K/AKT axis.Translational oncology · 2025Article
- Targeting Cancer Cell Fate: Apoptosis, Autophagy, and Gold Nanoparticles in Treatment Strategies.Current issues in molecular biology · 2025Review
- Optical parameter analysis and blood cells damage under 810 nm high-power IR laser irradiation before and post vitamin C and zinc supplementation.Lasers in medical science · 2025Article
- Imaging-guided precision hyperthermia with magnetic nanoparticles.Nature reviews bioengineering · 2025Article
- Iron and copper: critical executioners of ferroptosis, cuproptosis and other forms of cell death.Cell communication and signaling : CCS · 2023Review
- Chemo-radiation therapy of U87-MG glioblastoma cells using SPIO@AuNP-Cisplatin-Alginate nanocomplex.Heliyon · 2023Article
- Review
- Trace elements-based Auroshell gold@hematite nanostructure: Green synthesis and their hyperthermia therapy.IET nanobiotechnology · 2023Article
- Precise Construction of Dual-Promising Anticancer Drugs Associated with Gold Nanomaterials on Glioma Cancer Cells.Bioinorganic chemistry and applications · 2023Article
- Metal-Based Nanostructured Therapeutic Strategies for Glioblastoma Treatment-An Update.Biomedicines · 2022Review
- Synthesis and Characterization of Citrate-Stabilized Gold-Coated Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications.Molecules (Basel, Switzerland) · 2020Article
- Hyperthermia treatment advances for brain tumors.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2020Review
- Assessment of Gold-Coated Iron Oxide Nanoparticles as Negative T2 Contrast Agent in Small Animal MRI Studies.International journal of nanomedicine · 2020Article
- Investigation of the Dose-Enhancement Effects of Spherical and Rod-Shaped Gold Nanoparticles on the HeLa Cell Line.Galen medical journal · 2020Article
- Gadolinium-Based Nanoparticles for Theranostic MRI-Guided Radiosensitization in Hepatocellular Carcinoma.Frontiers in bioengineering and biotechnology · 2019Article
- Iron Metabolism in Cancer.International journal of molecular sciences · 2018Review
- Dual-Modality Therapy: Synergistic Enhancement of Radio-Hyperthermia by Gold-Gold Sulfide Nanoparticles in MCF-7 Cells.Avicenna journal of medical biotechnologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, gold-coated iron oxide nanoparticles (Au@IONPs) have received a great deal of attention in cancer therapy. In this in vitro study we aimed to investigate the anti-cancer effects of Au@IONPs core-shell nanoparticles when applied in thermo-radiotherapy. Moreover, we investigated the level of apoptosis induced in U87-MG human glioma cells after receiving a combinatorial treatment regimen (Au@IONPs + hyperthermia + radiotherapy). Firstly, the Au@IONPs nanocomplex was prepared and characterized. Cytotoxicity of the nanoparticles (various concentrations; 4 h incubation time) was investigated on U87-MG cells and finally the concentrations of 10 and 15 µg/mL were selected for further studies. After incubation of the cells with nanoparticles, they received hyperthermia (43 °C; 1 h) and then were immediately exposed to 6 MV X-ray (2 and 4 Gy). Following the treatments, MTT assay was used to analyze cell viability and flow cytometry was used to determine the level of apoptosis in each treatment group. The results revealed that nanoparticles have no significant cytotoxicity at concentrations lower than 10 µg/mL. Also, we observed that nanoparticles are able to enhance the cytotoxic effect of hyperthermia and radiation. The major mode of cell death was apoptosis when nanoparticles, hyperthermia and radiation were concomitantly applied to cancer cells. In conclusion, Au@IONP nanoparticle can be considered as a good thermo-radio-sensitizer which triggers significant levels of apoptosis in cancer therapy. In this in vitro study, we report the anti-cancer effects of gold-coated iron oxide nanoparticles (Au@IONPs) when applied in thermo-radiotherapy.
Indexed as
Identifiers
30203233What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.