ArticleSurgical endoscopy2019
Polyp size of 1 cm is insufficient to discriminate neoplastic and non-neoplastic gallbladder polyps.
Article in Surgical endoscopy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Interpretation, Reporting, Imaging-Based Workups, and Surveillance of Incidentally Detected Gallbladder Polyps and Gallbladder Wall Thickening: 2025 Recommendations From the Korean Society of Abdominal Radiology.Korean journal of radiology · 2025Guideline
- Risk of developing gallbladder cancer in patients with gallbladder polyps detected on transabdominal ultrasound: a systematic review and meta-analysis.The British journal of radiology · 2022Pooled it
- Analysis on clinicopathological characteristics and prognostic factors of adenoma-associated gallbladder carcinoma.Updates in surgery · 2026Article
- Efficacy and safety of ultrasound-guided radiofrequency ablation versus laparoscopic cholecystectomy in gallbladder polyps: a bicentric study.Scientific reports · 2026Article
- An integrative deep learning model based on dual-mode ultrasound for diagnosing gallbladder polyps.Insights into imaging · 2026Article
- Development of a preoperative prediction model for neoplastic polyps of the gallbladder based on a convolutional neural network model using ultrasonic images.Translational gastroenterology and hepatology · 2026Article
- Evaluating Multiple Input Strategies of Large Language Models for Gallbladder Polyps on Ultrasound: Comparative Study.JMIR medical informatics · 2025Article
- Revised Guidelines for the Treatment and Follow-Up of Gallbladder Polyps Do Not Reduce Unwarranted Cholecystectomies: Results of the POLYP Study.United European gastroenterology journal · 2025Article
- Early detection of gallbladder cancer: Current status and future perspectives.World journal of clinical oncology · 2025Review
- Response to "2025 Korean Society of Abdominal Radiology Recommendations on Gallbladder Polyps and Gallbladder Wall Thickening Warrant Further Investigation and Clarification".Korean journal of radiology · 2025Article
- The Predictive Roles of Tumour Markers, Hemostasis Assessment, and Inflammation in the Early Detection and Prognosis of Gallbladder Adenocarcinoma and Metaplasia: A Clinical Study.International journal of molecular sciences · 2025Article
- MiR-33 as a novel diagnostic biomarker for distinguishing cholesterol from adenomatous polyps: a case-control study.Hereditas · 2025Article
- Development and validation of a preoperative nomogram for predicting gallbladder adenoma.Surgical endoscopy · 2025Article
- Predicting Neoplastic Polyp in Patients With Gallbladder Polyps Using Interpretable Machine Learning Models: Retrospective Cohort Study.Cancer medicine · 2025Article
- A practical contrast-enhanced ultrasound risk prediction of gallbladder polyp: differentiation of adenoma from cholesterol polyp lesion.Abdominal radiology (New York) · 2025Article
- Predicting Neoplastic Gallbladder Polyps: The Role of Current Surgical Indications and Preoperative Images.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2025Article
- Current status of artificial intelligence analysis for the diagnosis of gallbladder diseases using ultrasonography: a scoping review.Translational gastroenterology and hepatology · 2025Review
- Intracholecystic Papillary-tubular Neoplasm (ICPN) of the Gallbladder: A Case Report Focusing on an Unexpected Pathological Finding.Recent patents on anti-cancer drug discovery · 2025Review
- Plain Computed Tomography for Differentiating Neoplastic and Non-neoplastic Pedunculated Gallbladder Polyps.Internal medicine (Tokyo, Japan) · 2024Article
- Endoscopic diagnosis and management of gallbladder carcinoma in minimally invasive era: New needs, new models.World journal of gastrointestinal oncology · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA significant proportion of gallbladder polyps are non-neoplastic, for which resection is not necessary. However, international guidelines advocate cholecystectomy for all polyps ≥ 1 cm. This study assessed a national cohort of histopathologically proven gallbladder polyps to distinguish neoplastic from non-neoplastic polyps.
methodsPALGA, the nationwide network and registry of histo- and cytopathology, was searched to identify all histopathologically proven gallbladder polyps between 2003 and 2013. All polyps and (focal) wall thickenings > 5 mm were included, and classified as neoplastic or non-neoplastic. Polyp subtype, size, distribution, presentation as wall thickening or protruding polyp, and presence of gallstones were assessed for neoplastic and non-neoplastic polyps. A decision tree to distinguish neoplastic and non-neoplastic polyps was made and diagnostic accuracy of 1 cm surgical threshold was calculated.
resultsA total of 2085 out of 220,612 cholecystectomies contained a polyp (0.9%). Of these polyps, 56.4% were neoplastic (40.1% premalignant, 59.9% malignant) and 43.6% non-neoplastic (41.5% cholesterol polyp, 37.0% adenomyomatosis, 21.5% other). Polyp size, distribution, and presence of gallstones were reported in 1059, 1739 and 1143 pathology reports, respectively. Neoplastic polyps differed from non-neoplastic polyps in size (18.1 mm vs 7.5 mm, p < 0.001), singularity (88.2% vs 68.2%, p < 0.001), wall thickening (29.1% vs 15.6%, p < 0.001), and presence of gallstones (50.1% vs 40.4%, p = 0.001). However, adenomyomatosis presented with similar characteristics as neoplastic polyps. Fifty percent of polyps were ≥ 1 cm surgical threshold (optimal surgical threshold based on ROC-curve); sensitivity for indicating neoplastic polyps was 68.1%, specificity was 70.2%, and positive and negative predictive values were 72.9% and 65.1%.
conclusionsThe prevalence of gallbladder polyps on cholecystectomy is low and many of the polyps are non-neoplastic. Clinicopathological characteristics differ between neoplastic and non-neoplastic polyps in general, but these cannot properly indicate neoplasia. The 1 cm surgical threshold has moderate diagnostic accuracy and is insufficient to indicate surgery for neoplastic gallbladder polyps.
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