Evidence map›Paper›PMID 30203200›Full record

ArticleSurgical endoscopy2019

Laparoscopic liver resection of hepatocellular carcinoma located in unfavorable segments: a propensity score-matched analysis from the I Go MILS (Italian Group of Minimally Invasive Liver Surgery) Registry.

Giovanni Battista Levi Sandri, Giuseppe Maria Ettorre, Luca Aldrighetti, Umberto Cillo, Raffaele Dalla Valle, Alfredo Guglielmi, Vincenzo Mazzaferro, Alessandro Ferrero, Fabrizio Di Benedetto, Salvatore Gruttadauria and 3 more

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In one paragraph

Article in Surgical endoscopy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Giovanni Battista Levi SandriDivision of General Surgery and Liver Transplantation, S. Camillo Hospital, Rome, Italy. gblevisandri@gmail.com.
Giuseppe Maria EttorreDivision of General Surgery and Liver Transplantation, S. Camillo Hospital, Rome, Italy.
Luca AldrighettiHepatobiliary Surgery, IRCCS San Raffaele Hospital, Milan, Italy. aldrighetti.luca@hsr.it.
Umberto CilloDepartment of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.
Raffaele Dalla ValleDepartment of Surgery, Parma University Hospital, Parma, Italy.
Alfredo GuglielmiDepartment of Hepatobiliary Surgery, G.B. Rossi Hospital, University of Verona, Verona, Italy.
Vincenzo MazzaferroHPB Surgery and Liver Transplantation, Department of Surgery, University of Milan, Milan, Italy.
Alessandro FerreroDepartment of HPB and Digestive Surgery, Ospedale Mauriziano Umberto I, Turin, Italy.
Fabrizio Di BenedettoHepato-Pancreato-Biliary Surgery and Liver Transplantation Unit, University of Modena and Reggio Emilia, Modena, Italy.
Salvatore GruttadauriaAbdominal Surgery and Organ Transplant Unit, Department for the Treatment and Study of Abdominal Diseases and Abdominal Transplantation, Mediterranean Institute for Transplantation and Specialization Therapies (IRCCS-ISMETT), Palermo, Italy.
Luciano De CarlisSurgical and Transplant Department, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Giovanni VennarecciDivision of General Surgery and Liver Transplantation, S. Camillo Hospital, Rome, Italy.
I Go MILS Group on HCC

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveLaparoscopic liver resection (LLR) for Hepatocellular Carcinoma (HCC) is one of the most important indications for the minimally invasive approach. Our study aims to analyze the experience of the Italian Group of Minimally Invasive Liver Surgery with laparoscopic surgical treatment of HCC, with a focus on tumor location and how it affects morbidity and mortality.

methods38 centers participated in this study; 372 cases of LLR for HCC were prospectively enrolled. Patients were divided into two groups according to the HCC nodule location. Group 1 favorable location and group 2 unfavorable location. Perioperative outcomes were compared between the two groups before and after a propensity score match (PS) 1:1.

resultsBefore PS in group 2 surgical time was longer; conversion rate was higher; postoperative transfusion and comprehensive complication index were also higher. PS was performed with a cohort of 298 patients (from 18 centers), with 66 and 232 patients with HCC in unfavorable and favorable locations, respectively. After PS matching, 62 patients from group 1 and group 2 each were compared. Operative and postoperative course were similar in patients with HCC in favorable and unfavorable LLR locations. Surgical margins were found to be identical before and after PS.

conclusionsThese results show that LLR in patients with HCC can be safely performed in all segments because of the extensive experience of all surgeons from multiple centers in performing traditional open liver surgery as well as laparoscopic surgery.

Indexed as

HepatectomyLaparoscopyAgedBlood TransfusionCarcinoma, HepatocellularFemaleHumansItalyLiver NeoplasmsMaleMargins of ExcisionMatched-Pair AnalysisMiddle AgedOperative TimePostoperative CarePostoperative ComplicationsChild BHepatocellular carcinomaIGoMILSLaparoscopic HCCLaparoscopic liver resectionPosterior segment

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.