Evidence map›Paper›PMID 30203199›Full record

ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2019

Asymptomatic focal calcium pyrophosphate crystal deposition within partially failed repair tissue after matrix-assisted autologous chondrocyte implantation.

Liang Gao, Tamás Oláh, Magali Cucchiarini, Henning Madry

Abstract readCase Reports
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In one paragraph

Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Liang GaoCenter of Experimental Orthopaedics, Saarland University, Homburg/Saar, Germany.
Tamás OláhCenter of Experimental Orthopaedics, Saarland University, Homburg/Saar, Germany.
Magali CucchiariniCenter of Experimental Orthopaedics, Saarland University, Homburg/Saar, Germany.
Henning MadryCenter of Experimental Orthopaedics, Saarland University, Homburg/Saar, Germany. henning.madry@uks.eu.ORCID http://orcid.org/0000-0003-1438-9670

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Possible failures of autologous chondrocyte implantation (ACI), a cell-based technique for articular cartilage repair, are not always clinically apparent and the underlying mechanisms largely remain unknown. This case report presents the first scenario in the literature highlighting an association of a medium-term partial failure of an advanced ACI procedure (matrix-assisted ACI) in the knee with focal asymptomatic calcium pyrophosphate deposition disease, a common inflammatory pyrophosphate arthropathy. The specific presence of CPPDs, resulting from increased biomechanical stresses in the repair tissue-cartilage and repair tissue-subchondral bone integration sites, together with the absence of cartilage regeneration was identified and possibly contributed to the partial failure.Level of evidence V.

Indexed as

Calcium PyrophosphateAdultCartilage, ArticularChondrocytesFemaleHumansKnee JointOrthopedic ProceduresOsteoarthritis, KneeTransplantation, AutologousCalcium PyrophosphateAsymptomatic failureCalcium pyrophosphate deposition diseaseKneeMatrix-assisted autologous chondrocyte implantationMid-term outcome

Identifiers

PMID30203199

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.