Evidence map›Paper›PMID 30203180›Full record

ReviewThe journal of headache and pain2018

The association between migraine and physical exercise.

Faisal Mohammad Amin, Stavroula Aristeidou, Carlo Baraldi, Ewa K Czapinska-Ciepiela, Daponte D Ariadni, Davide Di Lenola, Cherilyn Fenech, Konstantinos Kampouris, Giorgos Karagiorgis, Mark Braschinsky and 2 more

2 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The journal of headache and pain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 102 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed, 6 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05646160 naunknown statusnot on this map

Effects of Myofascial Trigger Points Therapy in Migraine.

TypeinterventionalSponsorJózef Piłsudski University of Physical EducationRan2018 to 2023Enrolled100ConditionsMigraine, Pain, Shoulder, Trapezius Muscle Strain Left, Trapezius Muscle Strain RightArmsIschemic Compression of Myofascial Trigger Points (IC-MTRPs)
NCT06857357 completednot on this mapstarted 2025, after this paper: background citation

Evaluation of Kinesiophobia in Patients With Headache Using the Tampa Kinesiophobia Scale Modified for Headache: Turkish Version, Validity and Reliability Study

Typeobservational_patient_registrySponsorBozok UniversityRan2025 to 2025Enrolled329ConditionsMigraineArmsQuestionnaires
3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 6 syntheses or guidelines pooled it, 221 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Trial
  8. Trial
  9. Trial
  10. Efficacy of a dual task protocol on neurophysiological and clinical outcomes in migraine: a randomized control trial.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Trial
  11. Trial
  12. Trial
  13. Trial
  14. Progress in pain mechanisms and management.Signal transduction and targeted therapy · 2026
    Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 5 countries.

Faisal Mohammad AminDepartment of Neurology, Danish Headache Center, Rigshospitalet Glostrup, University of Copenhagen, Valdemar Hansens Vej 5, 2600, Glostrup, Denmark. faisal@dadlnet.dk.
Stavroula Aristeidou1st Neurology of Department, Eginition Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Carlo BaraldiDepartment of Diagnostic, Medical Toxicology, Headache and Drug Abuse Research Center, Clinical and Public Health Medicine, University of Modena and Reggio Emilia, Modena, Italy.
Ewa K Czapinska-CiepielaEpilepsy and Migraine Treatment Centre, Kraków, Poland.
Daponte D Ariadni1st Neurology of Department, Eginition Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Davide Di LenolaDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina, Italy.
Cherilyn FenechHeadache Centre, Guys and St Thomas NHS Trust, London, UK.
Konstantinos Kampouris1st Neurology of Department, Eginition Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Giorgos Karagiorgis1st Neurology of Department, Eginition Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Mark BraschinskyNeurology Clinic's Headache Clinic, Tartu University Clinics, Tartu, Estonia.
Mattias LindeDepartment of Neuromedicine and Movement Science, NTNU Norwegian University of Science and Technology, Trondheim, Norway.
European Headache Federation School of Advanced Studies (EHF-SAS)
National and Kapodistrian University of Athens · GREginition Hospital · GRNorwegian University of Science and Technology · NOSapienza University of Rome · ITTartu University Hospital · EEUniversity of Copenhagen · DKUniversity of Modena and Reggio Emilia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is an unmet need of pharmacological and non-pharmacological treatment options for migraine patients. Exercise can be used in the treatment of several pain conditions, including. However, what exact role exercise plays in migraine prevention is unclear. Here, we review the associations between physical exercise and migraine from an epidemiological, therapeutical and pathophysiological perspective.

methodsThe review was based on a primary literature search on the PubMed using the search terms "migraine and exercise".

resultsLow levels of physical exercise and high frequency of migraine has been reported in several large population-based studies. In experimental studies exercise has been reported as a trigger factor for migraine as well as migraine prophylaxis. Possible mechanisms for how exercise may trigger migraine attacks, include acute release of neuropeptides such as calcitonin gene-related peptide or alternation of hypocretin or lactate metabolism. Mechanisms for migraine prevention by exercise may include increased beta-endorphin, endocannabinoid and brain-derived neurotrophic factor levers in plasma after exercise.

conclusionIn conclusion, it seems that although exercise can trigger migraine attacks, regular exercise may have prophylactic effect on migraine frequency. This is most likely due to an altered migraine triggering threshold in persons who exercise regularly. However, the frequency and intensity of exercise that is required is still an open question, which should be addressed in future studies to delineate an evidence-based exercise program to prevent migraine in sufferers.

Indexed as

Brain-Derived Neurotrophic FactorCalcitonin Gene-Related PeptideEndocannabinoidsExerciseExercise TherapyHumansMigraine DisordersOrexinsBDNF protein, humanBrain-Derived Neurotrophic FactorCALCA protein, humanCalcitonin Gene-Related PeptideEndocannabinoidsHCRT protein, humanOrexinsExercise headacheMigraine pathophysiologyMigraine treatment

Identifiers

PMID30203180
PMCPMC6134860
OpenAlexW2889817464

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.