Evidence map›Paper›PMID 30203108›Full record

ReviewCancer metastasis reviews2018

Cross-talk between lung cancer and bones results in neutrophils that promote tumor progression.

Patrick O Azevedo, Ana E Paiva, Gabryella S P Santos, Luiza Lousado, Julia P Andreotti, Isadora F G Sena, Carlos A Tagliati, Akiva Mintz, Alexander Birbrair

Abstract readReview
In one paragraph

Review in Cancer metastasis reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. The role and mechanism of neutrophils in oncolytic virus therapy.Experimental biology and medicine (Maywood, N.J.) · 2026
    Review
  4. Article
  5. Targeting inflammation as cancer therapy.Journal of hematology & oncology · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Glioma Pericytes Promote Angiogenesis by Producing Periostin.Cellular and molecular neurobiology · 2022
    Review
  10. Review
  11. Sympathetic nerve-adipocyte interactions in response to acute stress.Journal of molecular medicine (Berlin, Germany) · 2022
    Review
  12. Sensory nerves in the spotlight of the stem cell niche.Stem cells translational medicine · 2021
    Review
  13. Review
  14. Neural stem cell niche heterogeneity.Seminars in cell & developmental biology · 2019
    Review
  15. Staphylococcus epidermidis role in the skin microenvironment.Journal of cellular and molecular medicine · 2019
    Article
  16. Pericyte Plasticity in the Brain.Neuroscience bulletin · 2019
    Review
  17. Review
  18. Review
  19. Review
  20. Role of Schwann cells in cutaneous wound healing.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Patrick O AzevedoDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Ana E PaivaDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Gabryella S P SantosDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Luiza LousadoDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Julia P AndreottiDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Isadora F G SenaDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Carlos A TagliatiDepartment of Clinical and Toxicological Analysis, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Akiva MintzDepartment of Radiology, Columbia University Medical Center, New York, NY, USA.
Alexander BirbrairDepartment of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. birbrair@icb.ufmg.br.ORCID http://orcid.org/0000-0003-1015-2561
Universidade Federal de Minas Gerais · BRColumbia University Irving Medical Center · US

Funding

Therapeutically Exploiting a Newly Isolated Neural-Like Stem Cell Against GSBR01CA179072 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MINTZ, AKIVA · 2015 to 2020
$1.6M
Targeted Molecular Nano-Irradiation Against a Malignant Glioma BiomarkerR21NS067471 · NINDS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MINTZ, AKIVA · 2009 to 2010
$406k
NCI NIH HHS R01 CA179072NINDS NIH HHS R21 NS067471
6 · The paper itself

Abstract

Lung cancer is the leading cause of cancer mortality around the world. The lack of detailed understanding of the cellular and molecular mechanisms participating in the lung tumor progression restrains the development of efficient treatments. Recently, by using state-of-the-art technologies, including in vivo sophisticated Cre/loxP technologies in combination with lung tumor models, it was revealed that osteoblasts activate neutrophils that promote tumor growth in the lung. Strikingly, genetic ablation of osteoblasts abolished lung tumor progression via interruption of SiglecF

Indexed as

AnimalsCell CommunicationHumansLung NeoplasmsNeutrophilsOsteoblastsTumor MicroenvironmentLungNeutrophilsOsteoblastsTumor microenvironment

Identifiers

PMID30203108
PMCPMC6358512
OpenAlexW2890283953

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.