ArticleFEMS microbiology ecology2018
Metagenomic sequencing provides insights into microbial detoxification in the guts of small mammalian herbivores (Neotoma spp.).
Article in FEMS microbiology ecology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Phytochemicals Involved in Plant Resistance to Leporids and Cervids: a Systematic Review.Journal of chemical ecology · 2020Pooled it
- Influence of Plant Secondary Metabolites on intake, Detoxification Costs, and Microbial Communities in Deer.Journal of chemical ecology · 2026Article
- Diet change reveals asymmetric response in gene expression and microbial composition across the digestive tract of two closely related herbivores.BMC biology · 2026Article
- Forage quality shapes physiological and gut microbial responses in moose (Alces alces) of Isle Royale National Park.Scientific reports · 2026Article
- Comprehensive genome catalog analysis of the resistome, virulome and mobilome in the wild rodent gut microbiota.NPJ biofilms and microbiomes · 2025Article
- Recent genetic drift in the co-diversified gut bacterial symbionts of laboratory mice.Nature communications · 2025Article
- Recent genetic drift in the co-diversified gut bacterial symbionts of laboratory mice.bioRxiv : the preprint server for biology · 2024Article
- What Can the Gut Microbiota of Animals Teach Us about the Relationship between Nutrition and Burden of Lifestyle Diseases?Nutrients · 2024Review
- Immune-mediated hematological disease in dogs is associated with alterations of the fecal microbiota: a pilot study.Animal microbiome · 2023Article
- Multiscale variability in nutrients and secondary metabolites in a bat-dispersed neotropical fruit.Ecology and evolution · 2023Article
- Taxonomic, Genomic, and Functional Variation in the Gut Microbiomes of Wild Spotted Hyenas Across 2 Decades of Study.mSystems · 2023Article
- Metatranscriptomic Analyses Reveal Important Roles of the Gut Microbiome in Primate Dietary Adaptation.Genes · 2023Article
- You are more than what you eat: potentially adaptive enrichment of microbiome functions across bat dietary niches.Animal microbiome · 2021Article
- Interaction between intestinal microbiota and tumour immunity in the tumour microenvironment.Immunology · 2021Review
- Differential effects of elevated nest temperature and parasitism on the gut microbiota of wild avian hosts.Animal microbiome · 2021Article
- Age and sex-associated variation in the multi-site microbiome of an entire social group of free-ranging rhesus macaques.Microbiome · 2021Article
- Gut Microbiome Changes in Captive Plateau Zokors (Evolutionary bioinformatics online · 2021Article
- Natural diets promote retention of the native gut microbiota in captive rodents.The ISME journal · 2020Article
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Authors and funding
9 authors at 5 institutions in 1 country.
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Abstract
Microbial detoxification of plant toxins influences the use of plants as food sources by herbivores. Stephen's woodrats (Neotoma stephensi) specialize on juniper, which is defended by oxalate, phenolics and monoterpenes, while closely related N. albigula specialize on cactus, which only contains oxalate. Woodrats maintain two gut chambers harboring dense microbial communities: a foregut chamber proximal to the major site of toxin absorption, and a cecal chamber in their hindgut. We performed several experiments to investigate the location and nature of microbial detoxification in the woodrat gut. First, we measured toxin concentrations across gut chambers of N. stephensi. Compared to food material, oxalate concentrations were immediately lower in the foregut, while concentrations of terpenes remained high in the foregut, and were lowest in the cecal chamber. We conducted metagenomic sequencing of the foregut chambers of both woodrat species and cecal chambers of N. stephensi to compare microbial functions. We found that most genes associated with detoxification were more abundant in the cecal chambers of N. stephensi. However, some genes associated with degradation of oxalate and phenolic compounds were more abundant in the foregut chambers. Thus, microbial detoxification may take place in various chambers depending on the class of chemical compound.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.