Evidence map›Paper›PMID 30202882›Full record

SynthesisNutrition reviews2019

Carotenoids, vitamin A, and their association with the metabolic syndrome: a systematic review and meta-analysis.

May A Beydoun, Xiaoli Chen, Kanishk Jha, Hind A Beydoun, Alan B Zonderman, Jose A Canas

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrition reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  20. Natural Products in the Clinical Management of Metabolic Syndrome.Handbook of experimental pharmacology · 2025
    Review

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

May A BeydounNational Institute on Aging, National Institutes of Health, Intramural Research Program, Baltimore, Maryland, USA.
Xiaoli ChenMassachusetts Department of Public Health, Boston, Massachusetts, USA.
Kanishk JhaNemours Children's Clinic, Jacksonville, Florida, USA.
Hind A BeydounDepartment of Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Alan B ZondermanNational Institute on Aging, National Institutes of Health, Intramural Research Program, Baltimore, Maryland, USA.
Jose A CanasJohns Hopkins All Children's Hospital, St. Petersburg, Florida, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Context: Modifiable factors that reduce the burden of the metabolic syndrome (MetS), particularly plant-derived biomarkers, have been a recent focus of rising interest. Objective: This systematic review and meta-analysis, which follows PRISMA guidelines, evaluates evidence from a period of 20 years that links vitamin A and carotenoids with the occurrence of MetS and following the PRISMA guidelines. Data Sources: PubMed and Cochrane databases (January 1997 through March 2017) were systematically assessed for studies, including case-control, cross-sectional, and cohort studies, that evaluated the associations of MetS with carotenoids and retinyl esters and retinol (vitamin A). Data Extraction: Key measures of associations were harmonized into odds ratios (ORs) and 95% confidence intervals (95%CI) of MetS per 1 standard deviation (SD) of exposure using forest plots and random effects models that pooled data points from 11 cross-sectional studies. Begg's funnel and harvest plots were constructed. Results: An inverse association between total carotenoids and MetS was found [ORpooled, 0.66; 95%CI, 0.56-0.78; 1 SD ∼ 0.82 µmol/L; n = 5 studies]. This association was the strongest for β-carotene, followed by α-carotene and β-crypotoxanthin. No association was detected between retinol and MetS (ORpooled, 1.00; 95%CI, 0.88-1.13; 1 SD ∼ 2.14 µmol/L; n = 6 studies). Publication bias was absent, and harvest plots indicated consistency upon replication for β-carotene and total carotenoid exposures. Conclusions: This review and meta-analysis suggests that, unlike retinol, total and individual carotenoids were inversely related to MetS.

Indexed as

CarotenoidsCase-Control StudiesCohort StudiesCross-Sectional StudiesHumansMetabolic SyndromeCarotenoids

Identifiers

PMID30202882
PMCPMC6277204

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.