SynthesisHuman molecular genetics2018
Large-scale meta-analysis highlights the hypothalamic-pituitary-gonadal axis in the genetic regulation of menstrual cycle length.
Synthesis in Human molecular genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity.Human reproduction (Oxford, England) · 2024Pooled it
- A multi-level investigation of the genetic relationship between endometriosis and ovarian cancer histotypes.Cell reports. Medicine · 2022Pooled it
- Menstrual cycles during COVID-19 lockdowns: A systematic review and meta-analysis.Frontiers in reproductive health · 2022Pooled it
- Pooled it
- Recent Polygenic Adaptation in Heavily Fished Malawi Cichlids.Molecular ecology · 2026Article
- Identifying menstrual metrics as personal health markers: Age trends and individual footprints in temperature across 5674 cycles.Science advances · 2026Article
- Polymorphism of theLife (Basel, Switzerland) · 2026Article
- An Integrative Genome-Wide Analysis Reveals Shared and Subtype-Specific Genetic Links Between Endometriosis and Menstrual-Cycle-Related Traits.International journal of women's health · 2026Article
- Atlas of genetic and phenotypic associations across 42 female reproductive health diagnoses.Nature medicine · 2025Article
- Genetic Insights Into the Relationship Between Menstrual Factors and Site-/Age-Specific Bone Mineral Density.International journal of genomics · 2025Article
- A Cross-Sectional Study on Post-COVID-19 Menstrual Abnormalities in Women of Reproductive Age Group at a Tertiary Care Hospital.Obstetrics and gynecology international · 2025Article
- Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring.Nature aging · 2024Review
- Exploring the distribution of polymorphism across diverse breeds Worldwide in the bovineAnimal biotechnology · 2024Article
- Thyroid dysfunction in women with a menopausal syndrome.Przeglad menopauzalny = Menopause review · 2024Article
- Molecular mechanisms regulating natural menopause in the female ovary: a study based on transcriptomic data.Frontiers in endocrinology · 2023Article
- Sex Hormone Candidate Gene Polymorphisms Are Associated with Endometriosis.International journal of molecular sciences · 2022Article
- A GWAS in Idiopathic/Unexplained Infertile Men Detects a Genomic Region Determining Follicle-Stimulating Hormone Levels.The Journal of clinical endocrinology and metabolism · 2022Article
- Use of 'omics for endometrial timing: the cycle moves on.Human reproduction (Oxford, England) · 2022Article
- Identifying novel genetic loci associated with polycystic ovary syndrome based on its shared genetic architecture with type 2 diabetes.Frontiers in genetics · 2022Article
- Menstrual cycle length and modern living: a review.Current opinion in endocrinology, diabetes, and obesity · 2021Review
Corrections and comments
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Authors and funding
17 authors at 11 institutions in 4 countries.
Funding
Abstract
The normal menstrual cycle requires a delicate interplay between the hypothalamus, pituitary and ovary. Therefore, its length is an important indicator of female reproductive health. Menstrual cycle length has been shown to be partially controlled by genetic factors, especially in the follicle-stimulating hormone beta-subunit (FSHB) locus. A genome-wide association study meta-analysis of menstrual cycle length in 44 871 women of European ancestry confirmed the previously observed association with the FSHB locus and identified four additional novel signals in, or near, the GNRH1, PGR, NR5A2 and INS-IGF2 genes. These findings not only confirm the role of the hypothalamic-pituitary-gonadal axis in the genetic regulation of menstrual cycle length but also highlight potential novel local regulatory mechanisms, such as those mediated by IGF2.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.