Evidence map›Paper›PMID 30202817›Full record

ArticleHepatology communications2018

Whole-Exome Sequencing Study of Extreme Phenotypes of NAFLD.

Sarah E Kleinstein, Matthew Rein, Manal F Abdelmalek, Cynthia D Guy, David B Goldstein, Anna Mae Diehl, Cynthia A Moylan

Open access · goldAbstract read
In one paragraph

Article in Hepatology communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Sarah E KleinsteinInstitute for Genomic Medicine Columbia University New York NY.
Matthew ReinDurham Gastroenterology Consultants Duke University Health System Durham NC.
Manal F AbdelmalekDivision of Gastroenterology Duke University Health System Durham NC.
Cynthia D GuyDepartment of Pathology Duke University Health System Durham NC.
David B GoldsteinInstitute for Genomic Medicine Hammer Health Sciences New York NY.
Anna Mae DiehlDivision of Gastroenterology Duke University Health System Durham NC.
Cynthia A MoylanDivision of Gastroenterology Duke University Health System Durham NC.
Duke University Health System · USColumbia University · USDurham VA Health Care System · US

Funding

Viral Sequencing CoreU19AI067854 · NIAID · DUKE UNIVERSITY · PI BHARDWAJ, NINA · 2006 to 2011
$290.5M
Virus biology scientific research support componentUM1AI100645 · NIAID · DUKE UNIVERSITY · PI MCMICHAEL, ANDREW JAMES · 2012 to 2018
$204.7M
The Epilepsy Phenome/ Genome Project (EPGP)U01NS053998 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOWENSTEIN, DANIEL H · 2007 to 2013
$26.4M
The North American Mitochondrial Disease Consortium (NAMDC)U54NS078059 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HIRANO, MICHIO · 2011 to 2023
$17.5M
STUDY OF HEALTH OUTCOMES OF WEIGHT-LOSS (SHOW)U01DK057149 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI CLARK, JEANNE M · 1999 to 2020
$17.4M
Viral and Host Determinants of HIV-1 TransmissionU01AI067854 · NIAID · DUKE UNIVERSITY · PI HAYNES, BARTON F · 2005 to 2005
$14.9M
3 of 7 Epi4K: Sequencing, Biostatistics & Bioinformatics CoreU01NS077303 · NINDS · DUKE UNIVERSITY · PI EICHLER, EVAN, GOLDSTEIN, DAVID B. · 2011 to 2018
$13.3M
NEUROPATHOLOGY COREP30AG028377 · NIA · DUKE UNIVERSITY · PI WELSH-BOHMER, KATHLEEN ANNE · 2006 to 2011
$9.6M
Whole-genome sequencing for rare highly penetrant gene variants in schizophreniaRC2MH089915 · NIMH · DUKE UNIVERSITY · PI GOLDSTEIN, DAVID B. · 2009 to 2011
$4.6M
Prediction and Prevention of Hepatic Decompensation in Patients with CirrhosisU01DK130177 · NIDDK · DUKE UNIVERSITY · PI MATTHEW R. KAPPUS, Cynthia A Moylan · 2021 to 2026
$2.0M
Whole-genome sequencing in multiplex epilepsy familiesRC2NS070344 · NINDS · DUKE UNIVERSITY · PI GOLDSTEIN, DAVID B., OTTMAN, RUTH · 2009 to 2010
$2.0M
Characterizing Alcohol's Effects on Repair of Liver InjuryRC2AA019399 · NIAAA · DUKE UNIVERSITY · PI DIEHL, ANNA MAE ELIZABETH · 2009 to 2010
$2.0M
NIAAA NIH HHS RC2 AA019399NIAID NIH HHS U01 AI067854NIAID NIH HHS U19 AI067854NIAID NIH HHS UM1 AI100645NIA NIH HHS P30 AG028377NIDDK NIH HHS K23 DK062116NIDDK NIH HHS U01 DK057149NIDDK NIH HHS U01 DK130177NIMH NIH HHS K01 MH098126NIMH NIH HHS R01 MH097971NIMH NIH HHS RC2 MH089915NINDS NIH HHS RC2 NS070344NINDS NIH HHS U01 NS053998NINDS NIH HHS U01 NS077303NINDS NIH HHS U54 NS078059
6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous disease with highly variable outcomes. Patients with simple steatosis typically experience a benign course, whereas those with more advanced liver injury, nonalcoholic steatohepatitis (NASH), and advanced stage fibrosis suffer increased risk for complications such as cirrhosis, hepatic decompensation, and liver cancer. Genetic variants in patatin-like phospholipase domain-containing 3 (

Identifiers

PMID30202817
PMCPMC6128233
OpenAlexW2890505383

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.