ArticleAdvances in radiation oncology
Model evaluation of rapid 4-dimensional lung tomosynthesis.
Article in Advances in radiation oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Article
- Breathing-Adapted Imaging Techniques for Rapid 4-Dimensional Lung Tomosynthesis.Advances in radiation oncologyArticle
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis is an investigation of a lung motion digital tomosynthesis (DTS) model using combined stationary detector and stationary cold cathode x-ray sources at projection acquisition rates that exceed the present norms. The intent is to reduce anatomical uncertainties from artifacts inherent in thoracic 4-dimensional computed tomography (CT). METHODS AND MATERIALS: Parameters necessary to perform rapid lung 4-dimensional DTS were studied using a conventional radiographic system with linear motion of the x-ray source and a simple hypothetical hardware performance model. Hypothetical rapid imaging parameters of sweep duration, projections per second, pulse duration, and tube current (mA) were derived on the basis of 0.5 mm and 1 mm motion captures per phase, 10 and 15 breaths per minute (bpm), 10 to 40 mm breathing amplitude, and 2 signal-to-noise ratio (SNR) levels. Anterior-posterior and lateral projection images of a normal size anthropomorphic thorax phantom with iodine contrast inserts were collected and reconstructed with an algebraic algorithm to study the effects of reduced x-ray output associated with field emission cold cathodes composed of carbon nanotubes or metal Spindt-type. Radiographic projections were collected at 3 SNR levels that were set at standard clinical DTS milliampere-seconds (mAs) and reduced corresponding to 50% and 25% standard DTS mAs to simulate a reduced x-ray output.
resultsThe DTS SNR of the inserts was superior in all reconstructions at clinical mAs versus automatic exposure-control radiographs and superior in 3 of 4 at the 50% and 25% mAs levels. The most demanding performance parameters corresponding to 40 mm amplitude, 15 bpm, 0.5 mm motion capture limit, and 61 projections were sweep duration (10.4 msec), projection rate (5862 projections per second), pulse duration (0.161 msec), current 189 mA anterior-posterior, and 653 mA lateral.
conclusionsFeasibility depends on the output performance of stationary cold cathode hardware being developed for DTS. Present image receptor technology can accommodate frame acquisition rates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.