ArticleClinical and experimental reproductive medicine2018
Early fragment removal on
Article in Clinical and experimental reproductive medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07500337 (Effect of Embryo Defragmentation on Day 4), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Embryo Defragmentation on Day 4 (D4) on Blastocyst Development Rate and Clinical Outcomes in ART Cycles: a Prospective RCT
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- An Updated Understanding of Human Embryonic Fragmentation.Reproductive sciences (Thousand Oaks, Calif.) · 2026Pooled it
- Thinning or Opening: A Randomized Sibling-Embryo Pilot Trial on the Efficacy of Two Laser-Assisted Hatching Modes During the Extended Culture of Highly Fragmented Cleavage Embryos.Frontiers in endocrinology · 2022Trial
- Artificial removal of the zona pellucida at the pronuclear stage: an exploratory study to improve embryo fragmentation.F&S reports · 2024Article
- Enhancing clinical utility: deep learning-based embryo scoring model for non-invasive aneuploidy prediction.Reproductive biology and endocrinology : RB&E · 2024Article
- Cellular and Molecular Nature of Fragmentation of Human Embryos.International journal of molecular sciences · 2022Review
- Ultralow Oxygen Tension (2%) Is Beneficial for Blastocyst Formation of In Vitro Human Low-Quality Embryo Culture.BioMed research international · 2022Article
- Clinical Pregnancy After Elimination of Embryo Fragments Before Fresh Cleavage-stage Embryo Transfer.Journal of family & reproductive health · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether fragment removal on
methodsThis study was a retrospective analysis involving 191 IVF cycles in which all embryos had over 10% fragmentation (grade 3 or 4) on day 2 of the IVF-embryo transfer cycle from March 2015 to December 2017. IVF cycles were divided into the fragment removal group (n=87) and the no fragment removal group (n=104) as a control cohort. Before fragment removal, embryos with fragmentation on day 2 were incubated in Ca
resultsThere were no significant differences in the characteristics of the patients between the control and the fragment removal groups. After fragment removal and subsequent
conclusionEarly fragment removal on day 2 significantly improved the subsequent development and pregnancy outcomes of fragmented embryos.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.