Evidence map›Paper›PMID 30202727›Full record

ArticleIDCases2018

Cytomegalovirus infection in immunocompetent adults: Is observation still the best strategy?

Sarah Nangle, Subhashis Mitra, Steven Roskos, Daniel Havlichek

Abstract read
In one paragraph

Article in IDCases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Non-COVID-19 respiratory viral infection.Breathe (Sheffield, England) · 2022
    Review
  12. Article
  13. Article
  14. Acute Cytomegalovirus (CMV) Hepatitis in an Immunocompetent Adult.The American journal of case reports · 2020
    Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sarah NangleInfectious Diseases Fellow Division of Infectious Diseases, Department of Medicine College of Human Medicine, Michigan State University, East Lansing, MI, 48824, United States.
Subhashis MitraMedicine Division of Infectious Diseases, Department of Medicine College of Human Medicine, Michigan State University, East Lansing, MI, 48824, United States.
Steven RoskosMedicine Department of Family Medicine, College of Human Medicine, Michigan State University, East Lansing, MI, 48824, United States.
Daniel HavlichekMedicine Division of Infectious Diseases, Department of Medicine College of Human Medicine, Michigan State University, East Lansing, MI, 48824, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytomegalovirus (CMV) infection in immunocompetent patients generally resolves with few sequelae. However, it can cause severe and relapsing symptoms that can last for several weeks. Due to the self-limiting nature of CMV disease in immunocompetent individuals, criteria for specific antiviral therapy in this cohort are not well established. Additionally the adverse effect profile of currently available anti-CMV therapy limits its use in specific patient populations .We describe 3 immunocompetent adults who developed symptomatic CMV infection and were ill for several weeks. All patients had positive CMV viral assays and ultimately received anti-CMV therapy with significant improvement in symptoms within a few days of starting therapy. Choosing appropriate candidates for anti-CMV therapy, among mmunocompetent individuals, requires further research.

Indexed as

CytomegalovirusImmunocompetentPolymerase chain reactionValganciclovir

Identifiers

PMID30202727
PMCPMC6129681

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.