ReviewConcussion (London, England)2017
Understanding the interplay between mild traumatic brain injury and cognitive fatigue: models and treatments.
Review in Concussion (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 90 citations in OpenAlex.
- An explorative cross-sectional study on the association between immunological biomarkers in patients with chronic pain.Brain, behavior, & immunity - health · 2026Article
- Brain functional connectivity after Stroop task induced cognitive fatigue.Scientific reports · 2025Article
- A qualitative comparison of healthcare practitioners' perceptions regarding fatigue as a symptom in neurological conditions: insights from a tertiary care center in Saudi Arabia.Frontiers in rehabilitation sciences · 2025Article
- Return to work with fatigue after stroke: A complex occupational adaptation process.Scandinavian journal of occupational therapy · 2025Article
- Graph theory-based analysis of functional connectivity changes in brain networks underlying cognitive fatigue: An EEG study.PloS one · 2025Article
- Prospective evaluation of the relationship between cognition and recovery outcomes after cardiac arrest.Resuscitation · 2024Article
- A Semiautomated Protocol Towards Quantifying Vocal Effort in Relation to Vocal Performance During a Vocal Loading Task.Journal of voice : official journal of the Voice Foundation · 2024Article
- A multidisciplinary guideline-based approach to improving the sudden cardiac arrest care pathway: The Copenhagen framework.Resuscitation plus · 2024Article
- Outcome of severe COVID-19: spotlight on fatigue, fatigability, multidomain complaints and pattern of cognitive deficits in a case series without prior brain dysfunction and without COVID-19-related stroke and/or cardiac arrest.Journal of medical case reports · 2024Article
- A study protocol for risk stratification in children with concussion (RSiCC): Theoretical framework, design, and methods.PloS one · 2024Article
- Article
- The Effect of Meditation-Based Interventions on Patients with Fatigue Symptoms: A Systematic Review and Meta-Analysis.Psychologica Belgica · 2023Article
- Abnormal Dorsal Caudate Activation Mediated Impaired Cognitive Flexibility in Mild Traumatic Brain Injury.Journal of clinical medicine · 2022Article
- Fatigue after acquired brain injury impacts health-related quality of life: an exploratory cohort study.Scientific reports · 2021Article
- Comparison of the effects of transcranial direct current stimulation and mindfulness-based stress reduction on mental fatigue, quality of life and aggression in mild traumatic brain injury patients: a randomized clinical trial.Annals of general psychiatry · 2021Article
- Fatigue in relation to long-term participation outcome in aneurysmal subarachnoid haemorrhage survivors.Journal of rehabilitation medicine · 2021Article
- European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: post-resuscitation care.Intensive care medicine · 2021Article
- Does Intensive Training of Attention Influence Cognitive Fatigability in Patients With Acquired Brain Injury?Frontiers in neuroscience · 2021Article
- A Proposal for a Unifying Set of Definitions of Fatigue.Frontiers in psychology · 2021Article
- Sleep and stress in the acute phase of concussion in youth.Sports medicine and health science · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nearly 2 million traumatic brain injuries occur annually, most of which are mild (mTBI). One debilitating sequela of mTBI is cognitive fatigue: fatigue following cognitive work. Cognitive fatigue has proven difficult to quantify and study, but this is changing, allowing models to be proposed and tested. Here, we review evidence for four models of cognitive fatigue, and relate them to specific treatments following mTBI. The evidence supports two models: cognitive fatigue results from the increased work/effort required for the brain to process information after trauma-induced damage; and cognitive fatigue results from sleep disturbances. While there are no evidence-based treatments for fatigue after mTBI, some pharmacological and nonpharmacological treatments show promise for treating this debilitating problem. Future work may target the role of genetics, neuroinflammation and the microbiome and their role in complex cognitive responses such as fatigue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.