ReviewConcussion (London, England)2017
Understanding the effects of mild traumatic brain injury on the pupillary light reflex.
Review in Concussion (London, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04540445 (Utility of Pupillary Metrics in Diagnosis and Management of Concussion in Children), which is not on this map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Utility of Pupillary Metrics in Diagnosis and Management of Concussion in Children
Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Pooled it
- A systematic review of optical coherence tomography findings in adults with mild traumatic brain injury.Eye (London, England) · 2024Pooled it
- Visuospatial Attention Allocation as an Indicator of Cognitive Deficit in Traumatic Brain Injury: A Systematic Review and Meta-Analysis.Frontiers in human neuroscience · 2021Pooled it
- Model-based comparison of latency estimation methods for the pupillary light reflex.Scientific reports · 2026Article
- Correlation Between Accommodative Facility and Light-Evoked Pupil Responses in Individuals with History of Mild Traumatic Brain Injury.Journal of eye movement research · 2026Article
- Pupillary Hippus as a Biomarker: Spectral Signatures and Complexity Approaches in Autonomic and Clinical Contexts.Bioengineering (Basel, Switzerland) · 2025Review
- Evaluation of autonomic involvement in Parkinson's disease using pupillometry.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Video-based pupillometry using Fourier Mellin image correlation.Scientific reports · 2025Article
- Can the Pupillary Light Reflex and Pupillary Unrest Be Used as Biomarkers of Parkinson's Disease? A Systematic Review and Meta-Analysis.Diagnostics (Basel, Switzerland) · 2025Review
- Assessing the Inter-Rater and Inter-Trial Reliability of the NeurOptics Pupillary Light Response-3000 Pupillometer.International journal of sports physical therapy · 2025Article
- The diagnostic significance of pupillary reflex pathways: insights from classical examination and advanced pupillometry.Frontiers in neuroscience · 2025Review
- There Is Significant Within-Subject Variation in the Time from Light Stimulus to Maximum Pupil Constriction Among Healthy Controls.Journal of clinical medicine · 2024Article
- COLQ-Congenital myasthenic syndrome in an Iranian cohort: the clinical and genetics spectrum.Orphanet journal of rare diseases · 2024Article
- The Role of Concussion History and Biological Sex on Pupillary Light Reflex Metrics in Adolescent Rugby Players: A Cross-Sectional Study.Sports (Basel, Switzerland) · 2024Article
- Association of mild traumatic brain injury, post-traumatic stress disorder, and other comorbidities on photosensitivity.Optometry and vision science : official publication of the American Academy of Optometry · 2024Article
- Detecting feigned cognitive impairment using pupillometry on the Warrington Recognition Memory Test for Words.Journal of clinical and experimental neuropsychology · 2024Article
- The Role of Automated Infrared Pupillometry in Traumatic Brain Injury: A Narrative Review.Journal of clinical medicine · 2024Review
- Autonomic nervous system dysfunction in pediatric sport-related concussion: a systematic review.The Journal of the Canadian Chiropractic Association · 2023Article
- The Structural Layers of the Porcine Iris Exhibit Inherently Different Biomechanical Properties.Investigative ophthalmology & visual science · 2023Article
- Multisystem recovery after sport-related concussion in adolescent rugby players: a prospective study protocol.BMJ open · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pupillary light reflex represents an optimal visual system to investigate and exploit in the mild traumatic brain injury (mTBI) population. Static and dynamic aspects of the pupillary light reflex were investigated objectively and quantitatively in the mTBI population. Pupillary responsivity was found to be significantly delayed, slowed and reduced, but symmetrical in nature, and with a smaller baseline diameter, as compared with normals. Several pupillary parameters also discriminated between those with versus without photosensitivity. Thus, dynamic pupillometry provides several objective biomarkers for the presence of mTBI and photosensitivity, gives insight into the global sites of neurological dysfunction and possible related mechanisms, and should result in improved patient care.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.