ArticleThe Saudi dental journal2018
MIP-1α and MCP-1 as salivary biomarkers in periodontal disease.
Article in The Saudi dental journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Relationship Between MCP-1 Levels in GCF and Periodontitis: A Systematic Review With Meta-Analysis and Analysis of Molecular Interactions.Journal of cellular and molecular medicine · 2025Pooled it
- Essential Oil-Containing Mouthrinses for Plaque and Gingivitis Control: Formulation Chemistry, Human Salivary Biomarkers, Mechanistic Evidence, and Research Priorities.Molecules (Basel, Switzerland) · 2026Review
- The inflammation-pyroptosis axis links local and systemic biomarker profiles to active alveolar bone microstructural deterioration.Frontiers in physiology · 2026Article
- Effect of type 1 diabetes on the inflammatory response in periodontal disease.Frontiers in immunology · 2025Observational
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- Biomarkers of Parkinson's Disease: From Basic Research to Clinical Practice.Aging and disease · 2024Review
- Point-of-care diagnostic devices for periodontitis - current trends and urgent need.Sensors & diagnostics · 2024Review
- Article
- Salivary levels of inflammatory and anti-inflammatory biomarkers in periodontitis patients with and without acute myocardial infarction: implications for cardiovascular risk assessment.Frontiers in oral health · 2024Article
- Protein-based salivary biomarkers for the diagnosis of periodontal diseases: Systematic review and meta-analysis.Journal of Taibah University Medical Sciences · 2023Review
- Comparison of laser therapy and ozonated water on gingival inflammation in orthodontic patients with fixed appliances.Journal of clinical and translational research · 2021Article
- Predictive Periodontitis: The Most Promising Salivary Biomarkers for Early Diagnosis of Periodontitis.Journal of clinical medicine · 2021Review
- A new anabolic compound, LLP2A-Ale, reserves periodontal bone loss in mice through augmentation of bone formation.BMC pharmacology & toxicology · 2020Article
- Salivary concentrations of macrophage activation-related chemokines are influenced by non-surgical periodontal treatment: a 12-week follow-up study.Journal of oral microbiology · 2020Article
- Estimation of the salivary levels of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1α in periodontitis patients with and without diabetes in comparison to systemically and periodontally healthy individuals.Journal of Indian Society of PeriodontologyArticle
- Convergence of inflammatory response: Salivary cytokine dynamics in coronavirus disease 2019 and periodontal disease.Journal of Indian Society of PeriodontologyArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimChemokines released by different host cells when exposed to the components of periodontopathic bacteria induce and maintain an inflammatory response in the periodontium. The aim of the study was to estimate the salivary levels of two chemokines, macrophage inflammatory protein-1 alpha (MIP-1α) and monocyte chemo attractant protein-1 (MCP-1) in health, gingivitis and periodontitis and to evaluate their role as reliable salivary biomarkers in discriminating gingivitis and periodontitis from health.
methodsA cross sectional study was designed to estimate the levels of MIP-1α and MCP-1 in whole unstimulated saliva from 75 patients who were divided into healthy (Group 1, n = 25), gingivitis (Group 2, n = 25) and chronic generalized periodontitis (Group 3, n = 25). MIP-1α and MCP-1 levels were estimated by using ELISA and were correlated with clinical parameters. ROC curve analysis was done to determine the sensitivity and specificity of these biomarkers in distinguishing periodontal disease from health.
resultsBoth the biomarkers were detected in all the saliva samples. There was a statistically significant difference in the concentration of both the analytes in Group 3 and Group 2 compared with Group 1 (p < 0.001). ROC curve analysis showed 100% sensitivity and specificity for MIP-1α and MCP-1 in discriminating periodontitis from health. For discriminating gingivitis from health, MIP-1α had a higher sensitivity and specificity (100% & 88% respectively) compared to MCP-1(84.1% & 80% respectively).
conclusionThere is a substantial increase in the concentration of both MIP-1α and MCP-1 with increasing severity of periodontal disease. Both the analytes showed promising results as biomarkers for discriminating periodontal disease from health.
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