ReviewThe Saudi dental journal2018
A systematic review on antibacterial activity of zinc against
Review in The Saudi dental journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05427760 (Effect of Using Oxygen on the Diaper Dermatitis in Infants), which is not on this map. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Using Oxygen on the Diaper Dermatitis in Infants
Who cites it
56 citing papers in PubMed.
- A randomised, double-blind clinical study into the effect of zinc citrate trihydrate toothpaste on oral plaque microbiome ecology and function.Scientific reports · 2025Trial
- Antimicrobial Effects of Orthodontic Molar Tube Coated with ZnO Nanoparticles Using Electrophoretic Deposition Method: A Randomized Clinical Trial.Applied biochemistry and biotechnology · 2025Trial
- Antibacterial Interventions for Orthodontic Appliances; Surface Modifications, Coatings and Bulk-Incorporated Antibacterial Agents: Materials, Mechanisms and Clinical Application-A Scoping Review.Materials (Basel, Switzerland) · 2026Review
- Penetration enhancement effects of topically applied crosslinked hyaluronic acid.International journal of cosmetic science · 2026Article
- Nano-warfare in the oral cavity: antimicrobial strategies and mechanisms in nanodentistry.Odontology · 2026Review
- Antibiotic-free antimicrobial functionalization of PEEK via UV-induced self-initiation and N-halamine grafting.Journal of orthopaedic translation · 2026Article
- Oleyl-hyaluronate nanoparticles for enhanced peroral bioavailability of encapsulated Coenzyme Q10.Drug delivery and translational research · 2026Article
- Topical cream with essential oils, zinc and salicylic acid reduces pruritus and skin lesion scores in pruritic dogs.Australian veterinary journal · 2026Article
- Antimicrobial Materials Used in Coating Dental Implant Surfaces: State of the Art and Future Prospectives.Materials (Basel, Switzerland) · 2026Review
- AdcBC-dependent zinc uptake influences physiological responses inJournal of oral microbiology · 2026Article
- Influence of zinc-modified niobium nanoparticles incorporation in resinous monomers on mechanical properties.Brazilian dental journal · 2026Article
- Strategic incorporation of metal ions in bone regenerative scaffolds: multifunctional platforms for advancing osteogenesis.Regenerative biomaterials · 2025Review
- Endophytic and antagonisticFrontiers in microbiology · 2025Article
- Comparison of single bacteria and a bacterial reference community in a test against coated surfaces of varying copper content.Frontiers in microbiology · 2025Article
- Evaluation of anti-biofilm and anti-virulence effect of zinc sulfate on Staphylococcus aureus isolates.Scientific reports · 2024Article
- Review
- Insights into the Versatility of Using Atomic Absorption Spectrometry in Antibacterial Research.Molecules (Basel, Switzerland) · 2024Article
- Perception of Periodontitis Patients about Treatment Outcomes: A Cross-Sectional Study in Saudi Arabia.Healthcare (Basel, Switzerland) · 2024Article
- Systematic Review of Zinc's Benefits and Biological Effects on Oral Health.Materials (Basel, Switzerland) · 2024Review
- The potential of postharvest zinc treatment for preservation of pomegranate aril quality.Scientific reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of this study was to systematically review the growth inhibition effectiveness of zinc against
methodsLiterature search on PubMed, Medline, and science direct databases was carried out for in vitro studies published in English from 1990 to 2016, and the reported outcomes of minimum inhibitory concentration (MIC), minimum bactericidal concentrations (MBC), zone of inhibition (ZOI) and bacterial count method using colony forming unit (CFU) were used to assess the antibacterial effectiveness of zinc.
resultsSeventeen studies were included in this review. Seven studies reported MIC and MBC. Four studies reported ZOI, and eight studies reported CFU. MIC values using zinc chloride and zinc oxide nanoparticles were ranged from 0.025 to 0.2 mM and 0.390 to 500 ± 306.18 µg/ml respectively. MBC values using zinc oxide nanoparticles have ranged from 3.125 to 500 µg/ml. ZOI ranged from no inhibition zone to 21 ± 1.4 mm using 23.1% zinc oxide. A considerable reduction in the bacterial count was reported after adding zinc. However, only two studies have reported no inhibitory effect of zinc.
conclusionThis review indicated a significant growth inhibition effectiveness of zinc even at lower concentrations which indicate it's safely to be used in oral health products.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.