Evidence map›Paper›PMID 30202144›Full record

ArticleJournal of orthopaedics2018

Association of GDF-5 rs143383 polymorphism with radiographic defined knee osteoarthritis: A systematic review and meta-analysis.

Kazem Aghili, Mohammad Reza Sobhan, Masoud Mehdinezhad-Yazdi, Mohammadali Jafari, Seyed Mohsen Miresmaeili, Shohreh Rastegar, Mahta Mazaheri, Hossein Neamatzadeh

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In one paragraph

Article in Journal of orthopaedics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kazem AghiliDepartment of Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohammad Reza SobhanDepartment of Orthopedics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Masoud Mehdinezhad-YazdiDepartment of Orthopedics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mohammadali JafariDepartment of Emergency Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Seyed Mohsen MiresmaeiliDepartment of Biology, Science and Art University, Yazd, Iran.
Shohreh RastegarDepartment of Anesthesiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mahta MazaheriDepartment of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Hossein NeamatzadehDepartment of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess the association of GDF-5 rs143383 polymorphism with radiographic defined knee osteoarthritis (OA), a systematic review and meta-analysis was conducted.

methodsA total of 17 relevant case-control studies with 7424 cases and 11,310 controls was collected from several electronic databases up to June 2018.

resultsThe pooled results showed that GDF-5 rs143383 polymorphism was significantly associated with radiographic defined knee OA in overall and stratified analysis by ethnicity, source of controls and genotyping techniques.

conclusionsThe GDF-5 rs143383 polymorphism might be used as a relevant risk estimate for radiographic defined Knee OA.

Indexed as

GDF-5 geneKneeMeta-analysisOsteoarthritisRadiographic

Identifiers

PMID30202144
PMCPMC6128174

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.