ArticleScientific reports2018
Hypercapnia Alters Expression of Immune Response, Nucleosome Assembly and Lipid Metabolism Genes in Differentiated Human Bronchial Epithelial Cells.
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Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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0cells of the map it votes in
29citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
What it found
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Who cites it
29 citing papers in PubMed, 43 citations in OpenAlex.
- Hypercapnia Effects on Lung Function.Comprehensive Physiology · 2026Review
- Carbon Dioxide Inhalation-Risks for Health or Opportunity for Physical Fitness Development?Journal of clinical medicine · 2026Review
- Risks and benefits of face masks in children.Frontiers in pediatrics · 2026Review
- Hypercapnia as a Double-Edged Modulator of Innate Immunity and Alveolar Epithelial Repair: A PRISMA-ScR Scoping Review.International journal of molecular sciences · 2025Article
- Sensing molecular carbon dioxide: a translational focus for respiratory disease.Physiological reviews · 2025Review
- Bioenergetics and metabolism of the pulmonary endothelium. Scientific session I: ReSPIRE 2025.American journal of physiology. Lung cellular and molecular physiology · 2025Review
- Hypercapnia Increases Influenza A Virus Infection of Bronchial Epithelial Cells by Augmenting Cellular Cholesterol via mTOR and Akt.International journal of molecular sciences · 2025Article
- Carbon dioxide alleviates platelet storage lesions via stimulating fatty acid metabolism and reducing platelet glucose consumption.Research and practice in thrombosis and haemostasis · 2025Article
- Influence of the spaceflight environment on macrophage lineages.NPJ microgravity · 2024Review
- Myeloid Zfhx3 deficiency protects against hypercapnia-induced suppression of host defense against influenza A virus.JCI insight · 2024Article
- Carbon dioxide regulates cholesterol levels through SREBP2.PLoS biology · 2023Article
- Mild and moderate chronic hypercapnia elicit distinct transcriptomic responses of immune function in cardiorespiratory nuclei.Physiological genomics · 2023Article
- Hypercapnia alters mitochondrial gene expression and acylcarnitine production in monocytes.Immunology and cell biology · 2023Article
- Association between the time-varying arterial carbon dioxide pressure and 28-day mortality in mechanically ventilated patients with acute respiratory distress syndrome.BMC pulmonary medicine · 2023Article
- Extracorporeal Membrane Oxygenation for Refractory Asthma Exacerbations With Respiratory Failure.Chest · 2023Observational
- Hypercapnia increases ACE2 expression and pseudo-SARS-CoV-2 entry in bronchial epithelial cells by augmenting cellular cholesterol.Frontiers in immunology · 2023Article
- Hypercapnic Failure in Acute Exacerbated COPD Patients: Severe Airflow Limitation as an Early Warning Signal.Journal of clinical medicine · 2022Article
- Hypercapnia in COPD: Causes, Consequences, and Therapy.Journal of clinical medicine · 2022Review
- Hypercapnia selectively modulates LPS-induced changes in innate immune and DNA replication-related gene transcription in the macrophage.Interface focus · 2021Article
- Hypercapnia in the critically ill: insights from the bench to the bedside.Interface focus · 2021Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
S Marina Casalino-MatsudaDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America. marinamatsuda@northwestern.edu.ORCID 0000-0002-7566-4560
Naizhen WangDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Peder T RuhoffDepartment of Technology and Innovation, University of Southern Denmark, Odense, Denmark.
Hiroaki MatsudaDepartment of Biomedical Engineering, Northwestern University, Evanston, Illinois, United States of America.
Marie C NlendDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Aisha NairDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Igal SzleiferDepartment of Biomedical Engineering, Northwestern University, Evanston, Illinois, United States of America.
Greg J BeitelDepartment of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America.ORCID 0000-0003-4413-6324
Jacob I SznajderDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Peter H S SpornDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Northwestern University · USUniversity of Southern Denmark · DK
Funding
Tissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GR Scott Budinger · 2015 to 2026
$26.9MThe injurious effects of hypercapnia on the alveolar epitheliumR01HL085534 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2006 to 2018
$4.9MGenes Mediating Innate Immune Suppression by Hypercapnia in Mammals and FliesR01HL107629 · NHLBI · NORTHWESTERN UNIVERSITY · PI BEITEL, GREG J, SPORN, PETER H · 2012 to 2015
$1.5MHypercapnia and Suppression of Anti-viral Host DefenseR01HL131745 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SPORN, PETER H · 2017 to 2019
$1.2MHypercapnia and Suppression of Anti-viral Host DefenseR56HL131745 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SPORN, PETER H · 2016 to 2016
$391kNHLBI NIH HHS R01 HL085534NHLBI NIH HHS R01 HL107629NHLBI NIH HHS R01 HL131745NHLBI NIH HHS R56 HL131745NIA NIH HHS P01 AG049665
Abstract
Hypercapnia, the elevation of CO
Indexed as
BronchiCarbon DioxideCell DifferentiationCells, CulturedChronic DiseaseEpithelial CellsGene Expression ProfilingGene Expression RegulationHumansHypercapniaImmunity, InnateLipid MetabolismLung DiseasesNucleosomesRespiratory MucosaSarcoglycanopathiesCarbon DioxideNucleosomes
Identifiers
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Textmetadata
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.