Evidence map›Paper›PMID 30202044›Full record

ArticleJournal of human genetics2018

Gastric cancer may share genetic predisposition with esophageal squamous cell carcinoma in Chinese populations.

Linhua Yao, Fei Yu, Yingying Mao, Tianpei Wang, Qi Qi, Hui Ding, Jinchen Wang, Hongxia Ma, Juncheng Dai, Guoxin Zhang and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of human genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Linhua YaoDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Fei YuDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Yingying MaoDepartment of Epidemiology and Biostatistics, School of Public Health, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang, China.
Tianpei WangDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Qi QiDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Hui DingDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Jinchen WangDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Hongxia MaDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Juncheng DaiDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Guoxin ZhangDepartment of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China. guoxinz@njmu.edu.cn.
Guangfu JinDepartment of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China. guangfujin@njmu.edu.cn.ORCID http://orcid.org/0000-0003-0249-5337
Nanjing Medical University · CNHuzhou University · CNJiangsu Cancer Hospital · CNJiangsu Province Hospital · CNZhejiang Chinese Medical University · CN

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81373090National Natural Science Foundation of China (National Science Foundation of China) 81422042National Natural Science Foundation of China (National Science Foundation of China) 81521004
6 · The paper itself

Abstract

Many features are shared between esophageal cancer (EC) and gastric cancer (GC). This study aimed to explore whether known EC susceptibility loci are also important in the development of GC. A total of 21 genetic variants associated with EC in genome-wide association studies were evaluated with association of GC risk in 2631 cases and 4373 controls of Chinese ancestry. Single variant and weighted genetic scores (WGS) for esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), and overall EC were analyzed with GC risk, respectively. Genetic variants of rs2274223 in PLCE1 at 10q23.33 (per G allele: odds ratio (OR) = 1.26, 95% confidence interval (CI): 1.16-1.38, P = 6.51 × 10

Indexed as

Polymorphism, Single NucleotideAdenocarcinomaAldehyde Dehydrogenase, MitochondrialAsian PeopleBiomarkers, TumorCarcinoma, Squamous CellCase-Control StudiesChinaCyclic Nucleotide Phosphodiesterases, Type 4Esophageal NeoplasmsFollow-Up StudiesGenome-Wide Association StudyHumansPhosphoinositide Phospholipase CPrognosisStomach NeoplasmsAldehyde Dehydrogenase, MitochondrialALDH2 protein, humanBiomarkers, TumorCyclic Nucleotide Phosphodiesterases, Type 4PDE4D protein, humanPhosphoinositide Phospholipase Cphospholipase C epsilon

Identifiers

PMID30202044
OpenAlexW2891986181

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.