ArticleScientific reports2018
Candidate protein markers for radiation biodosimetry in the hematopoietically humanized mouse model.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 49 citations in OpenAlex.
- Point-of-Care Radiation Biodosimetry via a Body-Heated Reverse Transcription-Recombinase Polymerase Amplification Coupled to a Paper-Based Vertical Flow Immunoassay.Analytical chemistry · 2026Article
- A quantitative proteomics dataset for assessment and prediction of low dose X-ray radiation exposure in mice.bioRxiv : the preprint server for biology · 2026Article
- Centers for Medical Countermeasures against Radiation Consortium: Past, Present, and Beyond.Radiation research · 2025Review
- Intracellular lymphocyte protein biomarkers for early radiological triage in the human population.PloS one · 2025Article
- Validation of a blood biomarker panel for machine learning-based radiation biodosimetry in juvenile and adult C57BL/6 mice.Scientific reports · 2024Article
- BAX and DDB2 as biomarkers for acute radiation exposure in the human blood ex vivo and non-human primate models.Scientific reports · 2024Article
- Microfluidic measurement of intracellular mRNA with a molecular beacon probe towards point-of-care radiation triage.Sensors & diagnostics · 2024Article
- Cord Blood-Derived Endothelial Progenitor Cells Promote In Vivo Regeneration of Human Hematopoietic Bone Marrow.International journal of radiation oncology, biology, physics · 2023Article
- Longitudinal multi-omic changes in the transcriptome and proteome of peripheral blood cells after a 4 Gy total body radiation dose to Rhesus macaques.BMC genomics · 2023Article
- Identification of radiation responsive RBC membrane associated proteins (RMAPs) in whole-body γ-irradiated New Zealand white rabbits.Biotechnology reports (Amsterdam, Netherlands) · 2023Article
- Circulating microvesicles correlate with radiation proctitis complication after radiotherapy.Scientific reports · 2023Article
- Machine learning approach for quantitative biodosimetry of partial-body or total-body radiation exposures by combining radiation-responsive biomarkers.Scientific reports · 2023Article
- The NIAID/RNCP Biodosimetry Program: An Overview.Cytogenetic and genome research · 2023Review
- Paper-Based Vertical Flow Immunoassay for the Point-of-Care Multiplex Detection of Radiation Dosimetry Genes.Cytogenetic and genome research · 2023Article
- Development of a human peripheral blood ex vivo model for rapid protein biomarker detection and applications to radiation biodosimetry.PloS one · 2023Article
- Age and sex effects across the blood proteome after ionizing radiation exposure can bias biomarker screening and risk assessment.Scientific reports · 2022Article
- Dose Variations Using an X-Ray Cabinet to EstablishFrontiers in public health · 2022Article
- Small Molecule Responses to Sequential Irradiation with Neutrons and Photons for Biodosimetry Applications: An Initial Assessment.Radiation research · 2021Article
- Challenges and Strategies in the Development of Radiation Biodosimetry Tests for Patient Management.Radiation research · 2021Review
- Exploring the differentially expressed genes in human lymphocytes upon response to ionizing radiation: a network biology approach.Radiation oncology journal · 2021Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
After a radiological incident, there is an urgent need for fast and reliable bioassays to identify radiation-exposed individuals within the first week post exposure. This study aimed to identify candidate radiation-responsive protein biomarkers in human lymphocytes in vivo using humanized NOD scid gamma (Hu-NSG) mouse model. Three days after X-irradiation (0-2 Gy, 88 cGy/min), human CD45+ lymphocytes were collected from the Hu-NSG mouse spleen and quantitative changes in the proteome of the human lymphocytes were analysed by mass spectrometry. Forty-six proteins were differentially expressed in response to radiation exposure. FDXR, BAX, DDB2 and ACTN1 proteins were shown to have dose-dependent response with a fold change greater than 2. When these proteins were used to estimate radiation dose by linear regression, the combination of FDXR, ACTN1 and DDB2 showed the lowest mean absolute errors (≤0.13 Gy) and highest coefficients of determination (R
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.