ArticleNature communications2018
PoreDesigner for tuning solute selectivity in a robust and highly permeable outer membrane pore.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 70 citations in OpenAlex.
- Quantitative assessment of porin-mediated solute transport in biomimetic membranes.Applied microbiology and biotechnology · 2025Article
- Role of Ion Dehydration in Ion-Ion Selectivity of Dense Membranes.Environmental science & technology · 2025Review
- Viral escape-inspired framework for structure-guided dual bait protein biosensor design.PLoS computational biology · 2025Article
- A Practical Approach for Polarity and Quantity Controlled Assembly of Membrane Proteins into Nanoliposomes.Chembiochem : a European journal of chemical biology · 2025Article
- Enzyme structure correlates with variant effect predictability.Computational and structural biotechnology journal · 2024Article
- Recent Advances in Modeling Membrane β-Barrel Proteins Using Molecular Dynamics Simulations: From Their Lipid Environments to Their Assemblies.Methods in molecular biology (Clifton, N.J.) · 2024Article
- An Aquaporin Gene (Bioengineering (Basel, Switzerland) · 2023Article
- The energetic barrier to single-file water flow through narrow channels.Biophysical reviews · 2021Review
- Foldamer-based ultrapermeable and highly selective artificial water channels that exclude protons.Nature nanotechnology · 2021Article
- Membrane Protein Engineering with Rosetta.Methods in molecular biology (Clifton, N.J.) · 2021Article
- The Expanding Computational Toolbox for Engineering Microbial Phenotypes at the Genome Scale.Microorganisms · 2020Review
- Water in Nanopores and Biological Channels: A Molecular Simulation Perspective.Chemical reviews · 2020Review
- Protein Structure Prediction and Design in a Biologically Realistic Implicit Membrane.Biophysical journal · 2020Article
- Rapid fabrication of precise high-throughput filters from membrane protein nanosheets.Nature materials · 2020Article
- Synthetic protein-conductive membrane nanopores built with DNA.Nature communications · 2019Article
- Directed Evolution Reveals the Functional Sequence Space of an Adenylation Domain Specificity Code.ACS chemical biology · 2019Article
- A heuristic derived from analysis of the ion channel structural proteome permits the rapid identification of hydrophobic gates.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Rapid and Accurate Determination of Nanopore Ionic Current Using a Steric Exclusion Model.ACS sensors · 2019Article
- Heavy Metal Removal by Bioaccumulation Using Genetically Engineered Microorganisms.Frontiers in bioengineering and biotechnology · 2018Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Monodispersed angstrom-size pores embedded in a suitable matrix are promising for highly selective membrane-based separations. They can provide substantial energy savings in water treatment and small molecule bioseparations. Such pores present as membrane proteins (chiefly aquaporin-based) are commonplace in biological membranes but difficult to implement in synthetic industrial membranes and have modest selectivity without tunable selectivity. Here we present PoreDesigner, a design workflow to redesign the robust beta-barrel Outer Membrane Protein F as a scaffold to access three specific pore designs that exclude solutes larger than sucrose (>360 Da), glucose (>180 Da), and salt (>58 Da) respectively. PoreDesigner also enables us to design any specified pore size (spanning 3-10 Å), engineer its pore profile, and chemistry. These redesigned pores may be ideal for conducting sub-nm aqueous separations with permeabilities exceeding those of classical biological water channels, aquaporins, by more than an order of magnitude at over 10 billion water molecules per channel per second.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.