ArticleScientific reports2018
Auxin sensing is a property of an unstructured domain in the Auxin Response Factor ETTIN of Arabidopsis thaliana.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Genome-Wide Identification of thePlants (Basel, Switzerland) · 2026Article
- The tasiR-ARF pathway in plants: origin, functions, and interplay of miR-390, tasiRNAs and ARF3.Plant biology (Stuttgart, Germany) · 2026Review
- A 3-component module maintains sepal flatness in Arabidopsis.Current biology : CB · 2024Article
- Genome-Wide Identification, Expression, and Interaction Analysis of the Auxin Response Factor andInternational journal of molecular sciences · 2024Article
- Article
- What a tangled web it weaves: auxin coordination of stem cell maintenance and flower production.Journal of experimental botany · 2023Article
- Canonical and Alternative Auxin Signaling Systems in Mono-, Di-, and Tetraploid Potatoes.International journal of molecular sciences · 2023Article
- Save your TIRs - more to auxin than meets the eye.The New phytologist · 2023Review
- A model worker: Multifaceted modulation of AUXIN RESPONSE FACTOR3 orchestrates plant reproductive phases.Frontiers in plant science · 2023Review
- Hormones and Flower Development in Arabidopsis.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Molecular Mechanisms of Diverse Auxin Responses during Plant Growth and Development.International journal of molecular sciences · 2022Review
- Auxin Metabolite Profiling in Isolated and Intact Plant Nuclei.International journal of molecular sciences · 2021Article
- Glutathione Enhances Auxin Sensitivity in Arabidopsis Roots.Biomolecules · 2020Article
- tasiR-ARFs Production and Target Regulation during In Vitro Maize Plant Regeneration.Plants (Basel, Switzerland) · 2020Article
- Article
- Regulation of auxin transcriptional responses.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Review
- Patterning a Leaf by Establishing Polarities.Frontiers in plant science · 2020Review
- Non-canonical auxin signalling: fast and curious.Journal of experimental botany · 2019Article
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
Abstract
The plant hormone auxin regulates numerous aspects of the plant life cycle. Auxin signalling is mediated by auxin response factors (ARFs) that dimerise with modulating Aux/IAA repressors. ARF3 (ETTIN or ETT) is atypical as it does not interact with Aux/IAA repressors. It is proposed to be a non-canonical auxin sensor, regulating diverse functions essential for development. This sensing ability relies on a unique C-terminal ETT specific domain (ES domain). Alignments of ETT orthologues across the angiosperm phylum revealed that the length and sequence identities of ES domains are poorly conserved. Computational predictors suggested the ES domains to be intrinsically disordered, explaining their tolerance of insertions, deletions and mutations during evolution. Nevertheless, five highly conserved short linear motifs were identified suggesting functional significance. High-throughput library screening identified an almost full-length soluble ES domain that did not bind auxin directly, but exhibited a dose-dependent response in a yeast two-hybrid system against the Arabidopsis INDEHISCENT (IND) transcription factor. Circular dichroism confirmed the domain was disordered. The identification and purification of this domain opens the way to the future characterisation of the ETT auxin-sensing mechanism in planta and an improved understanding of auxin-mediated regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.