ArticleScientific reports2018
In vivo functional characterisation of pheromone binding protein-1 in the silkmoth, Bombyx mori.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 49 citations in OpenAlex.
- Biological and Biologically Inspired Functional Nanostructures: Insights into Structural, Optical, Thermal, and Sensing Applications.Advanced materials (Deerfield Beach, Fla.) · 2025Review
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- Pheromone-Binding Proteins in Pest Control: From Molecular Insights to Real-World Applications.Journal of agricultural and food chemistry · 2025Review
- Article
- Pheromone-Binding Protein 1 Performs a Dual Function for Intra- and Intersexual Signaling in a Moth.International journal of molecular sciences · 2024Article
- Molecular Characterization and Expression Patterns of Two Pheromone-Binding Proteins from the Diurnal MothInternational journal of molecular sciences · 2022Article
- Pheromone binding protein is involved in temporal olfactory resolution in the silkmoth.iScience · 2021Article
- The 40-Year Mystery of Insect Odorant-Binding Proteins.Biomolecules · 2021Review
- An Expanded Survey of the Moth PBP/GOBP Clade inFrontiers in physiology · 2021Article
- The role of SNMPs in insect olfaction.Cell and tissue research · 2021Review
- Molecular mechanisms of olfactory detection in insects: beyond receptors.Open biology · 2020Article
- Crystal structure of Epiphyas postvittana pheromone binding protein 3.Scientific reports · 2020Article
- The Drosophila odorant-binding protein 28a is involved in the detection of the floral odour ß-ionone.Cellular and molecular life sciences : CMLS · 2020Article
- Regulation of olfactory-based sex behaviors in the silkworm by genes in the sex-determination cascade.PLoS genetics · 2020Article
- Sexual-biased gene expression of olfactory-related genes in the antennae of Conogethes pinicolalis (Lepidoptera: Crambidae).BMC genomics · 2020Article
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
Male moths detect sex pheromones emitted by conspecific females with high sensitivity and specificity by the olfactory sensilla on their antennae. Pheromone binding proteins (PBPs) are highly enriched in the sensillum lymph of pheromone sensitive olfactory sensilla and are supposed to contribute to the sensitivity and selectivity of pheromone detection in moths. However, the functional role of PBPs in moth sex pheromone detection in vivo remains obscure. In the silkmoth, Bombyx mori, female moths emit bombykol as a single attractive sex pheromone component along with a small amount of bombykal that negatively modulates the behavioural responses to bombykol. A pair of olfactory receptor neurons, specifically tuned to bombykol or bombykal, co-localise in the trichodeum sensilla, the sensillum lymph of which contains a single PBP, namely, BmPBP1. We analysed the roles of BmPBP1 using BmPBP1-knockout silkmoth lines generated by transcription activator-like effector nuclease-mediated gene targeting. Electroantennogram analysis revealed that the peak response amplitudes of BmPBP1-knockout male antennae to bombykol and bombykal were significantly reduced by a similar percentage when compared with those of the wild-type males. Our results indicate that BmPBP1 plays a crucial role in enhancing the sensitivity, but not the selectivity, of sex pheromone detection in silkmoths.
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